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Diss Factsheets
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EC number: 603-923-2 | CAS number: 135590-91-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22.05.2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7370 (Dissociation constants in water)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hess. Ministerium für Umwelt, Energie, Landwirtschaft und Verbraucherschutz, Mainzer Straße 80, D65189, Wiesbaden
- Dissociating properties:
- no
Reference
Experimental Details
UV/VIS absorbance data were obtained from solutions of constant concentration under three different pH conditions.
A spectrophotometric background correction was done before each experiment using water / acetonitrile 90:10 as the blank solvent. For each of the UV/VIS spectra the test solution was filled into the cuvette with an optical path length of 1 cm. Subsequently the UV/VIS spectrum was recorded.
The UV/VIS spectra were recorded at pH 1.06, pH 5.76 and pH 10.01. The respective data for the extinction indicate no differences in the UV spectra of AE F107892, pure substance at these different pH values. The experiments were carried out at room temperature (21.6 °C to 22.9 °C).
Details of experiment A
Experiment |
Volume and concentration of added HCl |
Volume and concentration of added NaOH |
Resulting pH value |
A1 |
- |
- |
5.76 |
A2 |
10 mL - 1 mol/L |
- |
1.06 |
A3 |
- |
1 mL – 0.01 mol/L |
10.01 |
This means that no dissociation equilibrium occurred for AE F107892, pure substance, in the pH range 1 < pH < 10.
This result is equivalent to the conclusion that AE F107892, pure substance, showed no pKa value in the range 1 < pKa < 10.
Due to the lack of stability above pH 9, the UV/VIS spectra of the test item were recorded at pH pH 1.06, pH 5.76 and pH 10.01 at room temperature (approx. 22 °C). The test shows that the test item is sufficiently stable even at pH 10 for the duration of measurement.
The UV/VIS spectra showed neither significant differences in their course nor an isosbestic point. They were almost congruent, taking the UV absorption of the hydrochloric acid into account. No relevant difference was found between the UV/VIS absorption at the examined pH values.
No dissociation constant pKa was found in aqueous solution of Mefenpyr-diethyl (AE F107892), pure substance, in the pH-range of 1 < pH < 10.
Description of key information
The test substance (pure) shows no acidic or basic properties in the range of approximately 1 < pKa < 10 ( OECD Guideline 112).
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.