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EC number: 305-632-3 | CAS number: 94891-32-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental result of read across substance
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mention below
- Principles of method if other than guideline:
- WoE report is based on two short term toxicity study of fish for the test chemical:
1 and 2 - GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material : Aluminum, 2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)-1,2-dihydro-6,7-quinolinedisulfonate complexes
- Molecular formula : C18H11NO8S2.Al
- Molecular weight : 460.39 g/mol
- Smiles notation : O=C1c2ccccc2C(=O)C1=C1C=Cc2cc3c4cc2N{-}1.[Al]{3+}(.O{-}S3(=O)=O).O{-}S4(=O)=O
- Substance type : Organic
- Physical state : Solid - Analytical monitoring:
- yes
- Details on sampling:
- Concentrations: 100, 80, 60, 40, 20, and 10 mg/L
- Sample storage conditions before analysis: effluent samples were stored in amber glass bottles (2.0 L), transported to the laboratory well before 48-h in a lightproof ice chest, stored under refrigeration
(at 4 °C) in darkness until analysis - Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- 1. TEST ORGANISM
- Common name: Daphnia magna
- Source: laboratory stock culture
- Age at study initiation: 24 hr old neonatal
- Feeding during test : 24-h before experiment
- Food type: Selenastrum sp. and yeast powder
2. - Common name:
- Strain: Daphnia magna
- Source: Daphtoxkit F™ magna, a commercial kit that provides daphnids in the form of dormant eggs (ephippia)
- Age at study initiation : 24 h old neonates
- Feeding during test: prior 2 days of test
- Food type: lyophilized spirulina - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 1. 180.0 mg/l
- Test temperature:
- 1. 25 ± 2.0 °C
2. 20±1 °C - pH:
- 1. 7.8
- Nominal and measured concentrations:
- 2. 100 mg/L
- Details on test conditions:
- 1. Test vessel: 15 mL glass test tube
- Reference substance (positive control):
- yes
- Remarks:
- The experiment was validated with positive control test using reference substance potassium dichromate (K2Cr2O7)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: For 1 study
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4.271 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: For 2nd study: confidence interval (C.I.)-3.680-4.957
- Results with reference substance (positive control):
- 2 .potassium dichromate : 0.6-2.1 mg/l
- Validity criteria fulfilled:
- not specified
- Conclusions:
- 1.Test material when subjected to D. magna for 48 hrs the LC50 value was observed to be in the range 3.6-6.0 mg/l by chemical exposure.
2. The effect concentration of test material against Daphnia magna after 48 hrs was observed to be 4.271 mg/l - Executive summary:
Short term toxicity of Aluminum, 2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)-1,2-dihydro-6,7-quinolinedisulfonate complexes (94891 -32 -4) on the growth and other biological activity of aquatic invertebrates is predicted on the basis of it structurally and functionally similar read across chemicals. The studies are as mentioned below:
Short term toxicity study was performed to determine the toxic effect of the structurally and functionally similar read across chemicals on the invertebrates. Daphnia sp. Test material when used as a test material to evaluate its aquatic toxicity on Daphnia magna. The test animal was maintained. Twenty-four hours before the test, adult daphnids (gravid females) were sorted and the young one (neonates) produced from these adults were used in the experiment. Initially, a 24-h preliminary test was carried out at exposure concentrations of 100, 10, and 1.0 mg/LThe selected concentration for the test was 100, 80, 60, 40, 20, and 10 mg/L. After the exposure of test chemical for 24 hrs, the LC50 value was determine to be 6 mg/l and the 48hrs LC50 was determine in the range of 3.6 -6 mg/l. Based on the LC50, chemical was consider as toxic and classified as aquatic chronic 2 as per the CLP classification criteria.
Similar study was performed for another structurally and functionally similar read across chemicals. The acute aquatic toxicity was investigated with the 48 h daphnid immobilization assay for the test chemical. 24 h old neonatal Daphnia magna were used for the test. Test conducted under the static system for 48 hrs. The effect concentration was observed to be 4.271 mg/l after 48 h and the confidence interval C.I. was 3.680-4.957 mg/l. Based on the LC50, chemical was consider as toxic and can be consider to ba classified as aquatic chronic 2 as per the CLP classification criteria.
Thus based on the overall studies for the structurally and functionally similar read across chemical for Aluminum, 2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)- 1,2-dihydro-6,7- quinolinedisulfonate complexes (94891-32-4), it can be concluded that the test chemical was toxic and classifies as aquatic chronic 2 as per the CLP classification criteria.
Reference
Description of key information
1.Test material when subjected to D. magna for 48 hrs the LC50 value was observed to be in the range 3.6-6.0 mg/l by chemical exposure.
2. The effect concentration of test material against Daphnia magna after 48 hrs was observed to be 4.271 mg/l
Thus based on the overall studies for the structurally and functionally similar read across chemical for Aluminum, 2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)- 1,2-dihydro-6,7- quinolinedisulfonate complexes (94891-32-4), it can be concluded that the test chemical was toxic and classifies as aquatic chronic 2 as per the CLP classification criteria.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 6 mg/L
Additional information
Short term toxicity of Aluminum, 2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)-1,2-dihydro-6,7-quinolinedisulfonate complexes (94891 -32 -4) on the growth and other biological activity of aquatic invertebrates is predicted on the basis of it structurally and functionally similar read across chemicals. The studies are as mentioned below:
Short term toxicity study was performed to determine the toxic effect of the structurally and functionally similar read across chemicals on the invertebrates from journal. Daphnia sp. Test material when used as a test material to evaluate its aquatic toxicity on Daphnia magna. The test animal was maintained. Twenty-four hours before the test, adult daphnids (gravid females) were sorted and the young one (neonates) produced from these adults were used in the experiment. Initially, a 24-h preliminary test was carried out at exposure concentrations of 100, 10, and 1.0 mg/LThe selected concentration for the test was 100, 80, 60, 40, 20, and 10 mg/L. After the exposure of test chemical for 24 hrs, the LC50 value was determine to be 6 mg/l and the 48hrs LC50 was determine in the range of 3.6 -6 mg/l. Based on the LC50, chemical was consider as toxic and classified as aquatic chronic 2 as per the CLP classification criteria.
Similar study was performed for another structurally and functionally similar read across chemicals. The acute aquatic toxicity was investigated with the 48 h daphnid immobilization assay for the test chemical. 24 h old neonatal Daphnia magna were used for the test. Test conducted under the static system for 48 hrs. The effect concentration was observed to be 4.271 mg/l after 48 h and the confidence interval C.I. was 3.680-4.957 mg/l. Based on the LC50, chemical was consider as toxic and can be consider to be classified as aquatic chronic 2 as per the CLP classification criteria.
Thus based on the overall studies from peer reviewed journal for the structurally and functionally similar read across chemical for Aluminum, 2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)- 1,2-dihydro-6,7- quinolinedisulfonate complexes (94891-32-4), it can be concluded that the test chemical was toxic and classifies as aquatic chronic 2 as per the CLP classification criteria.
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