Registration Dossier
Registration Dossier
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EC number: 279-919-6 | CAS number: 82205-20-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Genotoxicity of the structural analogue of the target substance was assessed in two in vitro tests (OECD 471 and OECD 490). The test substance was mutagenic in the bacterial reverse mutation test, but tested negative in the in vitro mammalian cell gene mutation test.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Description of key information
Genotoxicity of the structural analogue of the target substance was assessed in an in vivo micronucleus test (OECD 474). The test substance was not genotoxic.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
No data is available for the target substance. Thus available data from a suitable structural analogue was used in a read-across approach. Details on the read-across rational are provided in section 13.
The chloride salt of the target substance was tested positive in a bacterial reverse mutation test (OECD 471), but was tested negative in the higher tier studies conducted in accordance with OECD 474 (in vivo micronucleus test) and 490 (in vitro mammalian cell gene mutation).
Justification for classification or non-classification
Genotoxicity of the target substance was assessed in a read-across approach. A suitable read-across substance was tested in an in vitro/in vivo testing battery. The substance was genotoxic in the bacterial reverse mutation test, but was tested negative in higher tier studies (OECD TG 474 and OECD TG 490). Therefore, it can be concluded based on a weight-of-evidence approach of the available data that no classification of the target substance is warranted.
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