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Diss Factsheets
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EC number: 257-913-4 | CAS number: 52434-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 5.07 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- ca. 6.5
- Conclusions:
- The solubility of Tris(2,3-Dibromoisopropyl)isocyanurate “AP 729” in milli-Q water is found to be 5.07 mg/L at pH 6.5 and 20°C, which concludes that the test item is poorly soluble in water.
- Executive summary:
The water solubility of Tris(2,3-Dibromoisopropyl)isocyanurate “AP 729” was determined as per OECD guideline 105, Water Solubility (Adopted: 27 July 1995) and United States Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances (TS-7101), Product Properties Test Guidelines, OPPTS 830.7840, “Water Solubility: Column Elution Method; Shake Flask Method”, EPA 712-C-98-041 (March 1998).
The water solubility of the test item Tris(2,3-Dibromoisopropyl)isocyanurate “AP 729” was found to be less than 10-2 g/L in milli-Q water during preliminary test. For further confirmation the definitive test was performed in milli-Q water under laboratory condition at 20°C by column elution method. The samples were analyzed for test item concentration by high performance liquid chromatography (HPLC). The solubility of the test item in milli-Q water with flow rate 25 mL/hour and 12.5 mL/hour was found to be 5.14 mg/L and 5.00 mg/L respectively. The calculated mean concentration was obtained to be 5.07 mg/L at 20°C.
Method validation parameters evaluated for Tris(2,3-Dibromoisopropyl)isocyanurate “AP 729” meets the acceptance criteria. The results obtained are within the specified limits. Thus, this method is suitable for the analysis of Tris(2,3-Dibromoisopropyl)isocyanurate “AP 729”.
The solubility of Tris(2,3-Dibromoisopropyl)isocyanurate “AP 729” in milli-Q water is found to be 5.07 mg/L with pH 6.5 at 20°C, which concludes that the test item is poorly soluble in water.
Reference
Description of key information
The result of the test for the measurement of logKow of 1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione showed that the substance appears to be insoluble in water, therefore a limit value has been estimated with Danish (Q)SAR: water solubility is calculated to be 1.14E-005 mg/L.
Additionally, an experimental study has been performed according to OECD Guideline 105 and the solubility of AP 729 in milli-Q water was found to be 5.07 mg/L at pH 6.5 and at 20°C, which concludes that the test item is poorly soluble in water.
Key value for chemical safety assessment
- Water solubility:
- 5.07 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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