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EC number: 252-354-2 | CAS number: 35086-59-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 13, 1999 - April 21, 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in GLP compliance and according to an OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,5-Diacetoxyacetophenon
- IUPAC Name:
- 3,5-Diacetoxyacetophenon
- Test material form:
- other: solid
- Details on test material:
- - Physical state: Brownish solid
- Analytical purity: Not indicated by sponsor; treated as 100% pure
- Lot/batch No.: 286
- Expiration date of the lot/batch: 16 December 1999
- Storage condition of test material: At room temperature in the dark
- Other:
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge: Waterschap de Maaskant', 's-Hertogenbosch, Netherlands
The sludge was kept under continuous aeration until
further treatment. The concentration of suspended
solids was 1.0 g/l in the concentrated sludge
(information obtained from the municipal sewage
treatment plant). Before use, the sludge was allowed
to settle for at least 30 minutes and the liquid
decanted for use as inoculum. Since the amount of
suspended solids was very low the amount of the
liquid for use as inoculum was increased to 40 ml/l of
mineral medium. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
Reference substance
- Reference substance:
- acetic acid, sodium salt
Results and discussion
- Test performance:
- The results of the biodegradation test were considered to be valid when:
the total C02 evolution in the inoculum blank at the end of the test did not normally
exceed 40 mg/l. lf values greater than 70 mg C02/I are obtained, the data and
experimental technique should be examined critically.
For the calculation of the total C02 evolution in the inoculum blank the volume of HCI
needed for the titrating of the remaining Ba(OH)2 of the inoculum blanks and for fresh
Ba(OH)2 was used.
the difference of duplicate values for the %-degradation of the test substance at the
plateau, at the end of the test or at the end of the 10-day window, as appropriate, was
less than 20.
the percentage degradation of the reference substance reached the Ievel for ready
biodegradability (60%) by 14 days.
Because of the stringency of the method, low values do not necessarily mean that the test
substance is not biodegradable under environmental conditions, but indicates more work will be
necessary to establish biodegradability.
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 30 - 48
- Sampling time:
- 28 d
- Remarks on result:
- other: bottle 1
- Details on results:
- The relative degradation values calculated from the measurements performed during the test
period revealed 30 and 48% degradation of 3,5-DIACETOXYACETOPHENON for A and B
respectively. Thus, the criterion for ready biodegradability (at least 60% degradation within 10
days of biodegradation exceeding 10%) was not met.
in the toxicity controlless than 25% degradation occurred within 14 days (based on ThC02 ).
Therefore, the test substance was found to have an inhibiting effect on microbial activity
BOD5 / COD results
- Results with reference substance:
- The positive control substance was degraded at least 60% within 10 days.
The total C02 release in the blank reached a total value of 37 mg C02 per 2 litres of medium.
The difference of duplicate values for %-degradation of 3,5-DIACETOXYACETOPHENON was
always less than 20.
Since all criteria for acceptability of the test were met, this study was considered to be valid.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not inherently biodegradable
- Conclusions:
- 3,5-DIACETOXYACETOPHENON was not readily biodegradable under the conditions of the
modified Sturm test presently performed.
However, it should be noted that in the toxicity control 3,5-DIACETOXYACETOPHENON was
found to have an inhibiting effect on microbial activity.
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