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EC number: 249-854-8 | CAS number: 29797-40-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1995 or before
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- The study was performed by the MITI, Japan and peer reviewed for NITE, Japan. The principles of the OECD Guideline 305 seem to have been followed.
The substance described in this dossier is an isomeric mixture of five position isomers of dichlorotoluene. The similarities concerning chemical structure and key intrinsic properties such as log Kow and water solubility lead to the assumption that the other intrinsic values and values for ecotoxicological endpoints will also be very similar for the individual isomers and the mixture of isomers and that therefore results obtained with isomers can be useful for the assessment of the mixture. - Reason / purpose for cross-reference:
- reference to other study
- Principles of method if other than guideline:
- Not reported, but the principles of the OECD Guideline 305 seem to have been followed.
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
None - Details on sampling:
- Not reported
- Vehicle:
- not specified
- Details on preparation of test solutions, spiked fish food or sediment:
- reported to be of "improved type for a volatile substance"
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- Not reported
- Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 8 wk
- Hardness:
- Not reported
- Test temperature:
- Not reported
- pH:
- Not reported
- Dissolved oxygen:
- Not reported
- TOC:
- Not reported
- Salinity:
- Not applicable
- Details on test conditions:
- Not reported
- Nominal and measured concentrations:
- 2 and 20 µg/L (not specified if nominal or measured)
- Reference substance (positive control):
- not specified
- Details on estimation of bioconcentration:
- Not reported
- Lipid content:
- 4.4 %
- Type:
- BCF
- Value:
- > 639 - < 939
- Remarks on result:
- other: Conc.in environment / dose:2 µg/L
- Type:
- BCF
- Value:
- > 606 - < 858
- Remarks on result:
- other: Conc.in environment / dose:20 µg/L
- Details on kinetic parameters:
- Not reported
- Metabolites:
- Not reported
- Results with reference substance (positive control):
- Not reported
- Details on results:
- Not reported
- Reported statistics:
- Not reported
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The BCF for 2,4 - dichlorotoluene was determined experimentally on carp (Cyprinus carpio) with a lipid content of 4.4%. The BCF was found to be 639 -939 at a concentration f 2 µg/L and 606 - 858 at 20 µg/L.
- Executive summary:
The BCF for 2,4-dichlorotoluene was determined experimentally by MITI on carp (Cyprinus carpio) with a lipid content of 4.4%. The BCF was found to be 639 -939 at a concentration of 2 µg/L and 606 - 858 at 20 µg/L.
Reference: database NITE, <=1995
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Calculation, peer reviewed by HSDB and therefore only summarised data available.
The substance described in this dossier is an isomeric mixture of five position isomers of dichlorotoluene. The similarities concerning chemical structure and key intrinsic properties such as log Kow and water solubility lead to the assumption that the other intrinsic values and values for ecotoxicological endpoints will also be very similar for the individual isomers and the mixture of isomers and that therefore results obtained with isomers can be useful for the assessment of the mixture. - Reason / purpose for cross-reference:
- reference to other study
- Principles of method if other than guideline:
- Calculation from a measured log Kow according to Hansch and Leo (1985, Medchem Project Claremont CA: Pomona College as cited in HSDB) and a regression-derived equation by Lyman Handbook of Chemical Property Estimation methods (1990, Amer. Chem. Soc. 995-4, 5-10) and Veith et al. (1980, An Evaluation of Using Partition Coefficients and Water Solubility to Estimate Bioconcentration Factors for Organic Chemicals in Fish, J. Fish. Res. Board Can. as cited in Lyman Handbook)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Not reported
- Details on sampling:
- Not applicable, calculation
- Vehicle:
- not specified
- Details on preparation of test solutions, spiked fish food or sediment:
- Not applicable, calculation
- Test organisms (species):
- no data
- Details on test organisms:
- No data
- Hardness:
- Not applicable, calculation
- Test temperature:
- Not applicable, calculation
- pH:
- Not applicable, calculation
- Dissolved oxygen:
- Not applicable, calculation
- TOC:
- Not applicable, calculation
- Salinity:
- Not applicable
- Details on test conditions:
- Not applicable, calculation
- Nominal and measured concentrations:
- Not applicable, calculation
- Reference substance (positive control):
- not required
- Details on estimation of bioconcentration:
- The equation given by Lymann (1990) is: log BCF = 0.76 log Kow - 0.23 and was referenced to be from Veith et al. (1980, see the references in "principle of method if other than guideline")
- Type:
- BCF
- Value:
- 1 000 dimensionless
- Basis:
- other: measured log Kow of 4.24
- Details on kinetic parameters:
- Not applicable, calculation
- Metabolites:
- Not applicable, calculation
- Results with reference substance (positive control):
- Not applicable, calculation
- Details on results:
- Not reported
- Reported statistics:
- Not reported
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The BCF value was calculated for 2,4-dichlorotoluene using a measured log kow of 4.24 according to Hansch and Leo (1985) and a regression-based equation by Lyman (1990) / Veith et al (1980, all references given in "principle of method if other than guideline")
- Executive summary:
The BCF value was calculated for 2,4-dichlorotoluene using a measured log kow of 4.24 according to Hansch and Leo (1985) and a regression-based equation by Lyman (1990) / Veith et al (1980, all references given in "principle of method if other than guideline") to be 1000.
Reference: HSDB, 2009
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Generally accepted calculation method, based on experimental log kow.
The substance described in this dossier is an isomeric mixture of five position isomers of dichlorotoluene. The similarities concerning chemical structure and key intrinsic properties such as log Kow and water solubility lead to the assumption that the other intrinsic values and values for ecotoxicological endpoints will also be very similar for the individual isomers and the mixture of isomers and that therefore results obtained with isomers can be useful for the assessment of the mixture. - Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Principles of method if other than guideline:
- The Bioconcentration factor BCF was calculated with the programme BCFBAF v.3.00 by using the experimental result of log Kow = 4.2 - 4.3 obtained with the HPLC method according to OECD Guideline 117 (Neuland, 2010).
- Details on estimation of bioconcentration:
- Estimation software: BCFBAF v.3.00
Equation used: log BCF = 0.6598 log Kow - 0.333 - Type:
- BCF
- Value:
- 274.3 dimensionless
- Remarks on result:
- other: based on log Kow = 4.2
- Type:
- BCF
- Value:
- 319.3 dimensionless
- Remarks on result:
- other: based on log Kow = 4.3
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The BCF was calculated to be 274.3 - 319.3.
- Executive summary:
The bioconcentration factor BCF was calculated to be 274.3 - 319.3. The programme BCFBAF v.3.00 and the experimental result of log Kow = 4.2 - 4.3 obtained with the HPLC method according to OECD Guideline 117 (Neuland, 2010) were used.
Reference: Keller, 2010
Referenceopen allclose all
Further information not provided
Other information not reported
Further information not provided
Description of key information
For one of the main isomers, 2,4-DCT, in a study in fish, the BCF was determined to be 606 – 939. (Reference: Database NITE, <=1995)
For the risk assessment, the value of 939 is chosen for the DCT-mixture. It is concluded that DCT mixture has a moderate bioaccumulation potential.
Key value for chemical safety assessment
- BCF (aquatic species):
- 939 dimensionless
Additional information
Weight of evidence:
The BCF for 2,4-dichlorotoluene was determined experimentally by MITI on carp (Cyprinus carpio) with a lipid content of 4.4%. The BCF was found to be 639 - 939 at a concentration of 2 µg/L and 606 - 858 at 20 µg/L. The principles of the OECD Guideline 305 seem to have been followed.
Reference: Database NITE, <=1995
The bioconcentration factor was calculated for dichloromethylbenzene mixture to be 274.3 - 319.3. The programme BCFBAF v.3.00 and the experimental result of log kow = 4.2 - 4.3 obtained with the HPLC method according to OECD Guideline 117 (Neuland, 2010) were used.
Reference: Keller, 2010
The BCF value was calculated for 2,4-dichlorotoluene to be 1000 by using a regression-based equation by Lyman (1990) / Veith et al (1980) based on a measured log kow of 4.24 according to Hansch and Leo (1985) .
Reference: Database HSDB, 2009
For the risk assessment, the experimentally determined value of 939 is chosen. It is concluded that DCT mixture has a moderate bioaccumulation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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