Registration Dossier
Registration Dossier
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EC number: 247-724-5 | CAS number: 26472-00-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 20 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
The primary findings in the available repeated dose study are an increase in hyaline droplets in the kidneys of all treated male but not female animals. Hyaline droplet accumulation in male rats is species and sex specific and is not predictive of an effect on other species.
Hepatocellular hypertrophy and an associated increase in liver weight were observed in females dosed at 100 and 300 mg/kg/day and in males dosed at 300 mg/kg/day.
Minimal to mild thyroid follicular hypertrophy was observed in males dosed at 300 mg/kg/day which was considered to be treatment related.
Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver; glandular: thyroids
Justification for classification or non-classification
No classification for repeated dose toxicity is indicated according to the general classification and labeling requirements
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