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EC number: 246-515-6 | CAS number: 24887-06-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- February 2010 - April 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study: The test was made in accordance with the „Revised OECD Principles of Good Laboratory Practice“ (Paris, 1997) as stated in the following guideline: OECD 111
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Physico-chemical properties
- Vapour pressure: 2.68 * 10-5 hPa at 20 °C
- Water solubility > 1,000 g/L
- log Pow < -3
- pKa1 6.6; pKa2 9.6;
- Base or acid catalysis of test material:
- UV absorption:
- Stability of test material at room temperature: stable at room temperature
OTHER PROPERTIES (if relevant for this endpoint) - Radiolabelling:
- no
- Details on sampling:
- Measurement of Samples:
1 ml sample solution was diluted with 100 ml of demineralised water. After addition of 2 ml formaldehyde solution 30 % and 2 drops phenolphthalein, the solution was adjusted to pH 3 with 0.05-m sulphuric acid. Then 2 ml starch solution were added and the test solution was titrated with I2 0.005-m (f = 0.9718) to blue colour. Every sample solution was titrated in duplicate. - Buffers:
- General: Deionised water was used for the solution of the test item and for the preparation of the buffer solutions.
Buffer-Solution, pH 4:
CH3COOH, 2M 16.0 mL
CH3COONa, 1M 8 mL
Water ad 200 mL
pH is adjusted to 4.00 using acetic acid.
Buffer-Solution, pH 7:
KH2PO4 1.7418 g
Water 50 mL
NaOH, 2M 2.98 mL
Wate ad 200 mL
pH is adjusted to 7.00 using NaOH 2M.
Buffer-Solution, pH 9:
H3BO3 0.7462 g
KCl 0.6188 g
Water 100 mL
NaOH, 2M 2.15 mL
Water ad 200 mL
pH is adjusted to 9.00 using NaOH 2M. - Estimation method (if used):
- -
- Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used:
Glassware: All test vessels was autoclaved before use. Duran 3.3 was used. Tubes, nominal volume 10 ml, with teflon seals were used as test
flasks.
Incubation Chambers: Incubation chamber #5 Memmert, adjustable to 50 0.5 °C. Usage and calibration follow-ing the corresponding SOP in
the current edition.
Other Instruments and Devices: The following instruments and devices were used for the performance of the study:
• Autoclave Sanyo MLS 3020
• pH-Meter wtw pH 540 GLP
• PT100-thermometer testo 720
• Adjustable pipettes with one-way tips Rainin® LAUS No.: 23, 30, 39
• Burette (maximum volume 10 mL)
• Sterilised nylon syringe filters 0,2 µm
• Standard laboratory glassware
TEST MEDIUM
- Kind and purity of water: deionised water
- Preparation of test medium: A stock solution was prepared by dissolving 300.2 mg test item in deionised water and filling up to volume in a 100 ml volumetric flask. Stock solution of the test item concentration: 3.0 g/L . The concentrations of the test item were measured by titration with iodine solution at the beginning und after storage at 50 °C for five days - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 1 500 mg/L
- Number of replicates:
- two per pH and one blank
- Positive controls:
- not specified
- Negative controls:
- not specified
- Preliminary study:
- Tier 1:
Performance: 08. Feb. – 15. Feb. 2010
pH values: 4.0; 7.0; 9.0
Buffers: see under "buffers"
Test temperature: 50 ± 0.5 °C
Number of replicates: two per pH and one blank - Test performance:
- see "Preliminary study"
- Transformation products:
- not measured
- Details on hydrolysis and appearance of transformation product(s):
- no transformation products measured.
- % Recovery:
- 68
- pH:
- 4
- Temp.:
- 20 °C
- Duration:
- 5 d
- % Recovery:
- 77
- pH:
- 7
- Temp.:
- 20 °C
- Duration:
- 5 d
- % Recovery:
- 66
- pH:
- 9
- Temp.:
- 20 °C
- Duration:
- 5 d
- Other kinetic parameters:
- none
- Details on results:
- MAJOR TRANSFORMATION PRODUCTS
At pH5:
- Range of maximum concentrations in % of the applied amount and day(s) of incubation when observed:see table 2
- Range of maximum concentrations in % of the applied amount at end of study period: see table 2
At pH7: see table 1
- Range of maximum concentrations in % of the applied amount and day(s) of incubation when observed: see table 2
- Range of maximum concentrations in % of the applied amount at end of study period: see table 2
At pH9: see table 1
- Range of maximum concentrations in % of the applied amount and day(s) of incubation when observed: see table 2
- Range of maximum concentrations in % of the applied amount at end of study period:see table 2 - Validity criteria fulfilled:
- yes
- Conclusions:
- The test shows that the test item hydrolyses depending on the pH value. The 50 % hydrolyses at pH 4 and pH 7 are estimated to be in a range between 7 and 8 days.
- Executive summary:
The pre-test indicates that is substance is not resistant against hydrolysis. Since the substance is readily biodegradable, no further testing is required.
Tiers 2 and 3 were not conducted on request of the sponsor.
Reference
A solution of the test item in water was mixed with buffer solutions (pH values: 4, 7, and 9), filtered sterile and degassed using sterile Argon. The resulting solutions were stored at 50 °C for aperiod of five days. Sam pies were taken at the beginning and after five days. The analysis of the sampies (titration with lodine) showed significant changes in the concentration
of the test item within five days.
table 1: (Tier 1): The consumptions of the titrations and the calculated concentration of the test item in the sample solutions:
Sample |
Volume 1 |
Volume 2 |
Mean Volume |
Conc. |
Blank pH 4 day 0 |
0.3 |
0.25 |
0.275 |
- |
Blank pH 7 day 0 |
0.3 |
0.3 |
0.3 |
|
Blank pH 9 day 0 |
0.3 |
0.3 |
0.3 |
|
09111902G pH 4 day 0 |
4.5 |
4.5 |
4.5 |
1500 |
09111902G pH 7 day 0 |
4.5 |
4.5 |
4.5 |
1500 |
09111902G pH 9 day 0 |
4.5 |
4.5 |
4.5 |
1500 |
Blank pH 4 day 5 |
0.3 |
0.3 |
0.3 |
- |
Blank pH 7 day 5 |
0.3 |
0.3 |
0.3 |
|
Blank pH 9 day 5 |
0.3 |
0.3 |
0.3 |
|
09111902G pH 4 day 5 a |
3.1 |
3.1 |
3.1 |
1020 |
09111902G pH 4 day 5 b |
3.1 |
3.1 |
||
09111902G pH 7 day 5 a |
3.4 |
3.4 |
3.475 |
1150 |
09111902G pH 7 day 5 b |
3.55 |
3.55 |
||
09111902G pH 9 day 5 a |
3.6 |
3.6 |
3.0 |
990 |
09111902G pH 9 day 5 b |
2.4 |
2.4 |
table 2: The measured concentrations and the decrease in tier 1:
Parameter |
pH 4.0 |
pH 7.0 |
pH 9.0 |
cm0 h |
1500 |
1500 |
1500 |
cm120 h Mean |
1020 |
1150 |
990 |
c after 5 days (% of start concentration) |
68 % |
77 % |
66 % |
Decrease |
32 % |
23 % |
34 % |
Description of key information
Recovery Rate (20°C, 5d) in % : 68 (pH 4); 77 (pH 7).
Half-life for hydrolyses (estimation): 7.5 d (pH 4); 7.2 (pH 7).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 7.5 d
- at the temperature of:
- 20 °C
Additional information
The pre-test indicates that is substance is not resistant against hydrolysis. Since the substance is readily biodegradable, no further testing is required.
The hydrolysis behaviour is not relevant for the classification. The substance is readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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