Registration Dossier
Registration Dossier
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EC number: 240-926-4 | CAS number: 16891-37-5
Endpoint summary
Administrative data
Description of key information
Magnesium diethyl dicarbonate rapidly hydrolyzes in aqueous environments (t1/2 < 1 minute) into carbon dioxide, ethanol and magnesium hydroxide (detailed description in section 5.1.2). Carbon dioxide is a natural gas. Valid study data on acute oral toxicity are available for the intermediate hydrolysis product magnesium ethanolate, as well as for the final hydrolysis products magnesium hydroxide and ethanol.
Intermediate hydrolysis product magnesium ethanolate
The intermediate hydrolysis product magnesium ethanolate showed an LD50 > 3160 mg/kg bw in a limit test equivalent to OECD TG 423 with male rats.
Hydrolysis product magnesium hydroxide
The final hydrolysis product magnesium hydroxide showed an LD50 (cut-off) > 5000 mg/kg bw in a limit test equivalent to OECD TG 423 under GLP with rats.
Hydrolysis product ethanol
The final hydrolysis product ethanol is a well-known substance of low oral toxicity. Several studies according to varying OECD guidelines have been included as a weight of evidence approach. The LD50 exceeded 5000 mg/kg bw in all of these studies. An inhalatory LC50 for ethanol could not be obtained; no deaths were reported for exposures up to 60,000ppm (114mg/l), which can be considered the saturated vapor concentration.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
Additional information
Justification for classification or non-classification
Available oral toxicity studies for the hydrolysis products magnesium hydroxide and ethanol showed an LD50(cut-off) > 5000 mg/kg resp. LD50> 5000 mg/kg bw.
Magnesium diethyl dicarbonate therefore does not meet the criteria for classification.
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