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Diss Factsheets
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EC number: 240-778-0 | CAS number: 16721-80-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
A comprehensive literature search and evaluation programme on animal and human sensitisation data of sodium hydrogensulfide has been conducted. All data sources were assessed by expert toxicologists for quality and reliability, as well as relevance for regulatory risk assessment under REACH. The results are attached to the technical dossier in a tabular report (IUCLID section 13).
Based on the caustic alkaline nature of the compound with extreme pH and the skin corrosive properties, animal testing for sensitisation potential is not scientifically justifiable as it would not provide any information relevant for the human risk assessment. Additionally, testing with a corrosive substance is not required in accordance with section 8.3, column 2, Annex VII of regulation (EC) 1907/2006, the skin sensitisation study does not need to be conducted as the available information indicates that the criteria are met for classification as corrosive to the skin and the substance is a strong base (pH≥11.5).
As a separate aspect, sulfides may be seen as ions endogenously occurring under physiological conditions, so that their role in normal human metabolism suggests that a sensitisation potential does not necessarily need to be expected.
Migrated from Short description of key information:
No data is available on skin sensitisation of sodium hydrogensulfide. As sodium hydrogensulfide will be classified for skin corrosivity and has a pH value above 11.5 no testing need to be conducted.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No data is available and no testing is required.
Justification for classification or non-classification
Sodium hydrogensulfide should not be classified as skin sensitizer or respiratory sensitizer for the following reasons:
According to EC Regulation No. 1272/2008, table 3.4.2 a, substances shall be classified as skin sensitizers (Category 1) in accordance with the following criteria:
(i) if there is evidence in humans that the substance can lead to sensitisation by skin contact in a substantial number of persons, or
(ii) if there are positive results from an appropriate animal test (see specific criteria in paragraph 3.4.2.2.4.1).
According to the CLP Regulation Annex I, Section 3.4.2.2 substances fulfilling the criteria for skin sensitisation will be classified as such in Category 1. If none of the above mentioned conditions are met (incl. specific considerations according to chapter 3.4.2.2.2), the substance need not be classified as a skin sensitizer. As for sodium hydrogensulfide no information, neither human nor animal data, is available, none of the specific conditions are fulfilled and no testing need to be conducted, it should not be classified as a skin sensitizer.
Substances shall be classified as respiratory sensitizers (Category 1) in accordance with the following criteria:
(a) if there is evidence in humans that the substance can lead to specific respiratory hypersensitivity and /or
(b) if there are positive results from an appropriate animal test.
According to the CLP Regulation Annex I, Section 3.4.2.1 substances fulfilling the criteria for respiratory sensitisation will be classified as such in Category 1.
As no such information is available for sodium hydrogensulfide, no classification is proposed on respiratory sensitisation.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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