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EC number: 231-048-2 | CAS number: 7423-42-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity, oral route: LD50 = 1411 mg/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- (SPF)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 98 - 126 g (mean: 108 g)
- Fasting period before study: The rats were not fed 16 hours before the application. 2 hours after administration of the product, the rats were given food again.
- Housing: The animals were kept in plastic cages on wood shavings.
- Diet: ALTROMIN 1324 (Altrogge), ad libitum.
- Water: ad libitum
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 4 %
- Doses:
- 800, 1250, 1600 and 2000 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: At study initiation, after 7 days and after 14 days.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight. - Statistics:
- The LD50 was determined by probit analysis (method according to Linder and Weber); the confidence limits were determined according to CAVALLI-SFORZA.
- Preliminary study:
- A preliminary test was carried out in which no gender differences could be detected. Therefore, the main test was performed with female rats only.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 411 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 293 - <= 1 539
- Mortality:
- Only in the lowest dose group of 800 mg/kg no mortality occured.
For details see section 'Any other information on results incl. tables'. - Clinical signs:
- other: Deadly poisoned animals died under balance disorders and accelerated breathing in abdominal or sternal position.
- Gross pathology:
- No findings were observed.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the conditions of this test an LD50 of 1411 mg/kg bw was determined in rats.
- Executive summary:
In an acute oral toxicity study equivalent to OECD guidleline 401, female Wistar rats (10/dose) were orally administered with a 4% solution of the test substance in sesame oil by oral gavage.
The test animals received the test substance at doses of 800, 1250, 1600 and 2000 mg/kg and were observed for 14 days. None of the animals had died in the lowest dose group. 2/10 and 8/10 animals had died at a dose of 1250 mg/kg and 1600 mg/kg, respectively and all animals had died in the highest dose group. Deadly poisoned animals died under balance disorders and accelerated breathing in abdominal or sternal position. The necropsy of the dead animals and survivors was without findings. Based on these result, an acute oral LD50 of 1411 mg/kg was observed in rats.
Reference
Table 1: Results of the acute oral toxicity study with the test item
Dose [mg/kg] |
Concentration in % |
Number of dead animals/ Number of total animals |
800 |
4 |
0/10 |
1250 |
4 |
2/10 |
1600 |
4 |
8/10 |
2000 |
4 |
10/10 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 411 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an acute oral toxicity study equivalent to OECD guidleline 401, female Wistar rats (10/dose) were orally administered with a 4% solution of the test substance in sesame oil by oral gavage (Hochst AG, 1995).
The test animals received the test substance at doses of 800, 1250, 1600 and 2000 mg/kg and were observed for 14 days. None of the animals had died in the lowest dose group. 2/10 and 8/10 animals had died at a dose of 1250 mg/kg and 1600 mg/kg, respectively and all animals had died in the highest dose group. Deadly poisoned animals died under balance disorders and accelerated breathing in abdominal or sternal position. The necropsy of the dead animals and survivors was without findings. Based on this result, an acute oral LD50 of 1411 mg/kg was observed in rats.
Justification for classification or non-classification
Classification, Labelling, and Packaging
Regulation (EC) No 1272/2008:
The available experimental test
data are reliable and suitable for classification purposes under
Regulation (EC) No 1272/2008. Based on available data on acute toxicity,
the test substance is classified as cat. 4, H302 (Harmful if swallowed)
according to Regulation (EC) No 1272/2008 (CLP), as amended for the
tenth time in Regulation (EU) No 2017/776.
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