Registration Dossier
Registration Dossier
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EC number: 224-638-6 | CAS number: 4433-79-8
Endpoint summary
Administrative data
Description of key information
Skin irritation:
KEY study according to OECD 404 (KEY_404_1992_HOECHST_ 92.0519): Not irritating
Supportive study not according to OECD 404 (NONKEY_404_1977_HUNTINGDON_Lonza Report No 0317): Not irritating
Supportive study not according to OECD 404 (NONKEY_404_1975_BIOTOX_Lonza Report No. 0316): Moderately irritating
Supportive study not according to OECD 404 (NONKEY_404_1974_HOECHST_0201/74): Not irritating
Eye irritation:
KEY study according to OECD 405 (KEY_405_1992_HOECHST_92.0563): Not irritating
Supportive study similar to OECD 405 (NONKEY_405_1977_HUNTINGDON_Lonza Report No 0318): Not irritating
Supportive study not according to OECD 405 (NONKEY_405_1974_HOECHST_0201/74): Not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Based on the findings in the key study the test item is neither skin irritating nor corrosive to skin. Data of three supporitive non key studies following guidelines which don't correspond with EU classification criteria are not inconsistent with these findings.
Based on the findings in the key study the test item is not irritating to eyes. Data of two supportive non key studies, (one similar to OECD 405, the other following a guideline not corresponding with EU classification criteria) are not inconsistent with these findings.
Justification for classification or non-classification
Available data don't meet criteria fo classification and labelling of REGULATION (EC) No 1272/2008 or Directiver 67/548/EEC related to skin corrosion/irritation and to eye irritation. Therefore classification and labelling is not warrantable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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