Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 223-981-9 | CAS number: 4151-51-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Stability
In accordance with column 2 of REACH Annex VIII, a study does not need to be conducted as the substance is highly insoluble in water.
But rapid hydrolysis (as for isocyanates in general) is considered for the substance. The hydrolysis products are mainly insoluble oligomeric and polymeric ureas. Theoretically the corresponding amine can be regarded which however is not formed in significant concentrations.
Using a read-across study from a chemically related substance it can be concluded that the test item undergoes a complete hydrolysis reaction in demineralized water within 24 hours and remains as hydrolysis product in form of an undissolved solid residue.
Biodegradation
The substance is considered to be "Not Readily Biodegradable".
Bioaccumulation
In accordance with column 2 of REACH Annex IX, the bioaccumulation in aquatic species study does not need to be conducted as direct or indirect exposure of the aquatic compartment does not occur.
Further according to REACH Annex IX, 9.3.2, column 2 the bioaccumulation study does not need to be conducted if the substance has a low potential for bioaccumulation. Due to the high reactivity of the isocyanates with water, bioaccumulation tests can in principle not be performed with these substances. Rapid hydrolysis of the substance (and isocyanates in general) makes approximation of equilibrium in the environment impossible resulting in a low potential for bioaccumulation.
The hydrolysis products are mainly insoluble, inert oligomeric and polymeric ureas and thus not bioavailable. Theoretically the corresponding amine can be regarded which however is not formed in significant concentrations.
Adsorption / desorption
The estimated carbon partition coefficient for the substance has no scientific meaning due to the reactivity of the substance with water (interstitial pore water). It is assumed that equilibrium partitioning to soil and associated organic matter is an irrelevant fate mechanism. As the substance will be rapidly reacted with associated pore water, adsorbed water, and organic matter associated with soil particles, no accumulation is expected in soil.
Henry's Law Constant
The Henry’s law constant (HLC) is directly calculated as a ratio of the vapour pressure to the water solubility yielding 0.621 Pa m3 mol at 20°C, indicating that the substance is low volatile from surface waters.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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