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EC number: 221-394-2 | CAS number: 3085-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Upon contact with water or moisture (e.g. within mucous membranes) aluminium tributanolate hydrolyses immediately to butan-1-ol and aluminium 3+ cations (as hydroxide and oxyhydroxide). Hence, toxicity is determined by the toxicity of these two species.
The acute oral toxicity of butan-1-ol in rat as expressed as LD50 is between 2510 and 4360 mg/kg bw (Jenner 1964, Smyth 1951). For aluminium nitrate and aluminium tri-isopropanolate oral LD50 values of 4280 mg/kg and 11300 mg/kg bw are reported (Smyth 1969).
For acute inhalation toxicity a LC50 of > 24.3 mg/L for butan-1-ol and a LC50 of 888 mg/m3 for aluminium flakes were derived (Korsak 1994, Reynolds 1986).
The dermal LD50 for butan-1-ol in rabbits is between 4200 and 5300 mg/kg bw (Patty 1982).
Butan-1-ol is not toxic via the dermal route, but is classified as harmful after swallowing (according to Annex VI of Regulation (EC) No 1272/2008). In several inhalation studies (not reported here) butan-1-ol showed local irritant effects on the respiratory system and transient effects on the CNS (drowsiness and dizziness) and is therefore classified as STOT SE 3, H335/H336 (according to Annex VI of Regulation EC 1272/2008).
Aluminium species (hydroxide or oxide) that may be formed during hydrolysis are not classified for acute toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No details available
- GLP compliance:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 360 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3 980 - <= 4 780
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 in rats is 4360 mg/kg bw
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- No. of animals per sex per dose:
- 5 males + 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: done but not specified
No additional details provided - Statistics:
- LD50 by Litchfield & Wilcoxon
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 510 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 220 - <= 2 840
- Mortality:
- death occurred between 4 and 18 hours post-dosing
- Clinical signs:
- other: Depression, coma
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the substance in rats is 2510 mg/kg bw
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 510 mg/kg bw
- Quality of whole database:
- Based on the available study on the hydrolysis product butan-1-ol
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- purpose of the investigations was to asses behavioural effects
- GLP compliance:
- not specified
- Test type:
- traditional method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Imp: DAK
- Weight at study initiation: 250-300 g
ENVIRONMENTAL CONDITIONS: no data
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: dynamic inhalation chamber (1.3 m3)
- Generation: by heating of liquid substance in washer
TEST ATMOSPHERE
- Brief description of analytical method used: GC with FID
- Samples taken: every 30 min
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- ca 3500, 5750 and 7900 ppm (10.8, 17.7 and 24.3 mg/L)
- No. of animals per sex per dose:
- 10 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: behavioural tests were performed immediately after the 4 hours exposure period
- Examinations performed:rotarod performance, hot plate performance
Rotarod performance was trained before exposure and only rats that were succesful in at least 10 trials were included in the study. Rotarod performance was measured before exposure and immediately therafter in 10 rats.
Hot plate perfomance was measured as latency to react immediately after exposure in 10 rats. - Statistics:
- Probit (EC50), ANOVA and Kruskall-Wallis
- Sex:
- male
- Dose descriptor:
- other: EC50 rotarod
- Effect level:
- 23.2 mg/L air
- Based on:
- test mat.
- 95% CL:
- >= 19.5 - <= 29.2
- Exp. duration:
- 4 h
- Remarks on result:
- other: 7559 ppm
- Sex:
- male
- Dose descriptor:
- other: EC50 hot plate test
- Effect level:
- 18.2 mg/L air
- Based on:
- test mat.
- 95% CL:
- >= 14.9 - <= 22.3
- Exp. duration:
- 4 h
- Remarks on result:
- other: 5901 ppm
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 24.3 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- no maortality at any of the concentrations tested
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LC 50 of the substance is > 24.3 mg/L. Below this concentration behavioural effects on rotarod performance and hot plate test are observed.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 24 300 mg/m³ air
- Quality of whole database:
- Based on the available study on the most volatile hydrolysis product butan-1-ol
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- standard work on toxicology
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no details provided
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rabbit
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 200 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 in rabbits is between 4200 and 5300 mg/kg bw.
Reference
An additional result in the same publication gave an LD50 of 5300 mg/kg bw in rabbits
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 200 mg/kg bw
- Quality of whole database:
- Aluminium hydroxide, aluminium oxide, aluminium oxyhydroxide are insoluble in water. Due to their insolubility it can be assumed that the absorption of these aluminium compounds via the skin will be limited. Therefore the LD50 is based on the other hydrolysis product butan-1-ol
Additional information
Upon contact with water or moisture (e.g. within mucous membranes) aluminium tributanolate hydrolyses immediately to butan-1-ol and aluminium 3+ cations (as hydroxide and oxyhydroxide). Hence, toxicity is determined by the toxicity of these two species.
Justification for classification or non-classification
Upon contact with water or moisture (e.g. within mucous membranes) aluminium tributanolate hydrolyses immediately to butan-1-ol and aluminium 3+ cations (as hydroxide and oxyhydroxide). Hence, toxicity is determined by the toxicity of these two species. Aluminium species are not classified for acute toxicity, but butan-1 -ol is classified as harmful after swallowing and as STOT SE 3, H335/H336 (according to Annex VI of Regulation EC 1272/2008). Therefore aluminium tributanolate will be classified as H302, H335 and H336 in a worst case approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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