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EC number: 217-284-9 | CAS number: 1798-50-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Test start: November 28 1997 - End of the experimental part of the test: January 15 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD, GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Version / remarks:
- Abridged version
- GLP compliance:
- yes
Test material
- Reference substance name:
- Azacyclonol
- EC Number:
- 204-092-5
- EC Name:
- Azacyclonol
- Cas Number:
- 115-46-8
- IUPAC Name:
- diphenyl(piperidin-4-yl)methanol
- Test material form:
- solid - liquid: suspension
- Details on test material:
- - Name of test material (as cited in study report): Azacyclonol-Base (Lepetit)
- Analytical purity: 98.3% (w/w)
- Lot/batch No.: 960050
- Analysis Certificate No.: 523928957/30795 dated 01.04.1997
- Expiration date of the lot/batch: 10-09-1998
Constituent 1
Test organisms
- Test organisms (species):
- activated sludge of a predominantly industrial sewage
- Details on inoculum:
- - Origin: waste water treatment plant in the city of Frankfurt am Main in Sindlingen
- Type of inoculum: washed activated sludge of a municipal wastewater treatment plant
- Preparation of the suspension: activated sludge sediment was centrifuged three times and then resuspended in water with 0.9% NaCl.
- Quantity of inoculum: 450 mL/L sludge suspension
- Sludge content: 21.8 g/L (centrifuged sludge sediment)
- Solids: 3.56 g/L (dry matter)
- Content in the final volume testing: 1.6 g/L (dry matter)
Study design
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 3 h
Test conditions
- Test temperature:
- Audit temperature: 18.6°C to 20.3°C
- pH:
- Audit pH: 8.4 to 8.9 after incubation
- Nominal and measured concentrations:
- Highest concentration of test material: 1000 mg/L
Lowest concentration of test material: 31.3 mg/L
Spacing factor for test concentrations: ca. 2 (factor between concentration values) - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol (3,5-DCP)
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- ca. 56 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Remarks on result:
- other: 18 mg/L to 97 mg/L
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 206 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Remarks on result:
- other: 124 mg/L to 358 mg/L
- Duration:
- 3 h
- Dose descriptor:
- other: EC80
- Effect conc.:
- ca. 759 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Remarks on result:
- other: 421 mg/L to 2633 mg/L
- Results with reference substance (positive control):
- The EC50 of the reference substance 3,5-dichlorophenol following value was obtained: 16 mg/L (95 % CL: 10 to 25 mg/L).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 of Azacyclonol base compared to activated sludge (waste water treatment plant) is in the range> 100 to 1000 mg/L.
Given that Azacyclonol base will decrease the acidity as observed in short term toxicity on fish (cf 6.1.1), the ecotoxicity profile of free base could beused as reference.
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