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EC number: 209-608-2 | CAS number: 587-98-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from abstract of peer reviewed publication.
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The absorption, metab. and excretion of [14C]metanil yellow was studied in rats.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material : sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate
- Molecular formula : C18H14N3O3S.Na
- Molecular weight: 375.383 g/mol
- Smiles notation : c1(Nc2ccccc2)ccc(\N=N\c2cc(ccc2)S(=O)(=O)[O-])cc1.[Na+]
- InChl : 1S/C18H15N3O3S.Na/c22-25(23,24)18-8-4-7-17(13-18)21-20-16-11-9-15(10-12-16)19-14-5-2-1-3-6-14;/h1-13,19H,(H,22,23,24);/q;+1/p-1/b21-20+;
- Substance type: Organic
- Physical state: Solid - Radiolabelling:
- yes
- Species:
- rat
- Strain:
- not specified
- Details on species / strain selection:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on exposure:
- single oral dose of 5 mg/kg
- Duration and frequency of treatment / exposure:
- single dose
- Dose / conc.:
- 5 mg/kg diet
- No. of animals per sex per dose / concentration:
- not specified
- Control animals:
- not specified
- Positive control reference chemical:
- not specified
- Details on study design:
- not specified
- Details on dosing and sampling:
- not specified
- Statistics:
- not specified
- Preliminary studies:
- not specified
- Type:
- absorption
- Results:
- single dose of 5 mg/kg was administered orally
- Type:
- distribution
- Results:
- Liver, kidney, spleen, and testis retained no count whereas 13.6% of the radioactivity was retained by gastrointestinal tract.
- Type:
- metabolism
- Results:
- Metabolites of metanil yellow which were characterized by TLC and IR, NMR, and mass spectroscopic studies as metanilic acid and p-aminodiphenylamine.
- Type:
- excretion
- Results:
- 80.5% of the dose was excreted in the urine and feces within 96 h, with the majority being accounted for in the feces.
- Metabolites identified:
- yes
- Details on metabolites:
- Analaysis of urine and feces detected two azo-reduction metabolites of metanil yellow which were characterized by TLC and IR, NMR, and mass spectroscopic studies as metanilic acid and p-aminodiphenylamine.
- Bioaccessibility (or Bioavailability) testing results:
- not specified
- Conclusions:
- The substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate was determined to be readily absorbed, metabolised and rapidly excreted in the urine and feces within 96 h, with the majority being accounted for in the feces (80.5% in 96 hrs). Hence the substance is assumed to possess no bio-accumulation potential based on study results.
- Executive summary:
The absorption, metabolism and excretion of [14C] metanil yellow was studied in rats. Following administration of a single oral dose of 5 mg dye (7.6mCi)/kg, 80.5% of the dose was excreted in the urine and feces within 96 h, with the majority being accounted for in the feces. Liver, kidney, spleen, and testis retained no count whereas 13.6% of the radioactivity was retained by gastrointestinal tract. Analaysis of urine and feces detected two azo reduction metabolites of metanil yellow which were characterized by TLC and IR, NMR, and mass spectroscopic studies as metanilic acid and p-aminodiphenylamine. Hence the substance is assumed to possess no bio-accumulation potential based on study results.
Reference
Description of key information
Basic toxicokinetics:
The substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate was determined to be readily absorbed, metabolised and rapidly excreted in the urine and feces within 96 h, with the majority being accounted for in the feces (80.5% in 96 hrs). Hence the substance is assumed to possess no bio-accumulation potential based on study results.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Basic toxicokinetics:
The absorption, metabolism and excretion of [14C] metanil yellow was studied in rats. Following administration of a single oral dose of 5 mg dye (7.6mCi)/kg, 80.5% of the dose was excreted in the urine and feces within 96 h, with the majority being accounted for in the feces. Liver, kidney, spleen, and testis retained no count whereas 13.6% of the radioactivity was retained by gastrointestinal tract. Analaysis of urine and feces detected two azo reduction metabolites of metanil yellow which were characterized by TLC and IR, NMR, and mass spectroscopic studies as metanilic acid and p-aminodiphenylamine.Hence the substance is assumed to possess no bio-accumulation potential based on study results.
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