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EC number: 205-685-1 | CAS number: 147-14-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion: non-irritating (GLP study according to OECD TG 404)
Eye irritation: non-irritating (pre-GLP study similar to OECD TG 405)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Batch no SF20927
- blue powder
- storage conditions: room temperature in the dark
- no data on purity available - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: David Percival Ltd, Moston, Sandbach, Cheshire, UK
- Age at study initiation: 12-20 weeks
- Weight at study initiation: 2 - 3.5kg
- Housing: individulally
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 to 23°C
- Humidity (%): 30-70%
- Air changes (per hr): at least fifteen changes per hour
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: June 1 2004 To: June 8 2004 - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- 0.5g
- Duration of treatment / exposure:
- 4h
- Observation period:
- 24, 48 and 72 hours
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5cm x 2.5 cm
- Type of wrap if used: surgical adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): gentle swabbing with cotton wool soaked in 74% Industrial Methylated Spirits
- Time after start of exposure:4h
OBSERVATION TIME POINTS
24, 48 and 72 hours
SCORING SYSTEM: Draize
- Method of calculation: according to OECD 404 - Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: reversibility is not applicable, as there were no findings.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48h
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Copper phthalocyanine is not irritating to rabbit skin.
Reference
Skin Reaction |
Observation Time |
IndividualScores-Rabbit Numberand sex |
Total |
|||
|
||||||
104 Male |
105 Male |
106 Male |
||||
|
1 Hour |
1 STA |
1 STA |
1 STA |
( 3 ) |
|
Erythema/Eschar |
24 Hours |
1 STA |
1 STA |
1 STA |
3 |
|
Formation |
48 Hours |
O STA |
O STA |
O STA |
( 0 ) |
|
|
72 Hours |
O STA |
O STA |
O STA |
0 |
|
|
1 Hour |
0 |
0 |
0 |
( 0 ) |
|
Oedema Formation |
24 Hours |
0 |
0 |
0 |
0 |
|
|
48 Hours |
0 |
0 |
0 |
( 0 ) |
|
|
72 Hours |
0 |
0 |
0 |
0 |
|
Sum of 24 and 72-hour Readings (S) |
: |
3 |
|
|
||
Primary Irritation Index (S/6) |
: |
3/6=0.5 |
|
|
STA = Blue colored staining of the skin
( ) =Total values not used for calculation of primary irritation index
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- ; 50 mm3 (one sharp-edged spoon) of test material applied (OECD0.1 ml,< 100 mg); 2 animals were used (OECD: 3); the eyes were not washed out after 24 h (OECD: washing after 24 h); observation period was 3 days (OECD: 2); exam. using fluorescein (OECD no)
- Principles of method if other than guideline:
- BASF-Test:
Before OECD guideline 405 was established, eye irritation was tested using an internal method. White Vienna rabbits were used. Usually approximately 50 µl or one sharp-edged spoon in case of solids of the test substance were applied to the conjunctival sac of one eye of 2 animals. The non- or saline- treated eye served as control. In studies with solids, talcum powder was alternatively used as control. The animals were observed several times on the treatment day and up to 8 days afterwards, and findings were recorded on working days.
The eyes were not washed out after 24 h as specified in OECD Guideline 405, which could be critical for solids which thus remained on the cornea for several days, causing mechanical damage. Probably, this would have been less severe if it had been washed out after 1 day. - GLP compliance:
- no
- Remarks:
- GLP was not compulsory at the time the study was conducted.
- Specific details on test material used for the study:
- - Analytical purity: 100 %
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Average weight at study initiation: ca. 3.0 kg
- Diet: Altromin-MS (Altrogge, Lage/L. Germany), ad libitum
- Water: ad libitum - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the second eye of the same rabbit was treated with 50 mg talcum powder.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: one sharp-edged spoon of the test substance, undiluted; ca. 50 mg - Duration of treatment / exposure:
- 24 h; the substance was not washed out
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- One sharp-edged spoon of the undiluted, solid test substance was applied to the right conjuntival sac of one male and one female Vienna White rabbit. The left eye, treated with physiological saline, served as a control. The substance was not washed out.
Ocular reactions were recorded after 10 min, 1, 3 and 24 hours, as well as 2 and 3 days after instillation using a BASF-scoring system, which is convertible into the current OECD Draize scheme. For the evaluation the BASF scores given in the raw data were converted to Draize scores. The reading time points used for assessment were 24, 48 and 72 hours after application. - Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- other: 24-48-72 h
- Score:
- 0.16
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: finding was also seen in control eye
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Irritant / corrosive response data:
- Slight conjunctivae redness as well as substance residues were observed in both eyes of all animals after 1 min, 1 hour and 3 hours of test substance instillation. In animal 1, no more findings were seen after 24 hours in both eyes. In animal 2, very slight conjunctivae chemosis was seen only in the left control eye after 1 and 3 hours and slight conjunctivae redness was still seen in both eyes after 24 hours. No more findings were seen after 48 hours in both eyes.
- Interpretation of results:
- GHS criteria not met
Reference
Table 1: Eye irritation parameters of 2 rabbits after application of the test material; scores were determined according to the method of Draize
Reading time point |
Animal 1, treated eye (right) |
||||
Cornea |
Iris |
Conjunctivae redness |
Conjunctivae chemosis |
Additional findings |
|
10 min |
0 |
0 |
1 |
0 |
substance residues |
1 h |
0 |
0 |
1 |
0 |
substance residues |
3 h |
0 |
0 |
1 |
0 |
substance residues |
24 h |
0 |
0 |
0 |
0 |
|
48 h |
0 |
0 |
0 |
0 |
|
72 h |
0 |
0 |
0 |
0 |
|
Reading time point |
Animal 1, control eye (left) |
||||
Cornea |
Iris |
Conjunctivae redness |
Conjunctivae chemosis |
Additional findings |
|
10 min |
0 |
0 |
1 |
0 |
substance residues |
1 h |
0 |
0 |
1 |
0 |
substance residues |
3 h |
0 |
0 |
1 |
0 |
substance residues |
24 h |
0 |
0 |
0 |
0 |
|
48 h |
0 |
0 |
0 |
0 |
|
72 h |
0 |
0 |
0 |
0 |
|
Reading time point |
Animal 2, treated eye (right) |
||||
Cornea |
Iris |
Conjunctivae redness |
Conjunctivae chemosis |
Additional findings |
|
10 min |
0 |
0 |
1 |
0 |
substance residues |
1 h |
0 |
0 |
1 |
0 |
substance residues |
3 h |
0 |
0 |
1 |
0 |
substance residues |
24 h |
0 |
0 |
1 |
0 |
|
48 h |
0 |
0 |
0 |
0 |
|
72 h |
0 |
0 |
0 |
0 |
|
Reading time point |
Animal 2, control eye (left) |
||||
Cornea |
Iris |
Conjunctivae redness |
Conjunctivae chemosis |
Additional findings |
|
10 min |
0 |
0 |
1 |
0 |
substance residues |
1 h |
0 |
0 |
1 |
1 |
substance residues |
3 h |
0 |
0 |
1 |
1 |
substance residues |
24 h |
0 |
0 |
1 |
0 |
|
48 h |
0 |
0 |
0 |
0 |
|
72 h |
0 |
0 |
0 |
0 |
|
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion:
In a skin irritation/corrosion study according to OECD guideline 404 and GLP, 0.5g of the test material, moistened with 0.5 ml of distilled water was introduced under a 2.5 cm x 2.5 cm cotton gauze patch and placed in position on the clipped skin of 3 male New Zealand White rabbits. Four hours after application the patches and any residual test material were removed. Approximately one hour following the removal of the patches, and 24, 48 and 72 hours later, the test sites were examined for evidence of primary irritation and scored according to Draize.
Very slight erythema was noted at all treated skin sites one hour after patch removal and at the 24-hour observation. No evidence of skin irritation was noted at the 48-hour observation. Therefore, it was concluded that the test substance is not irritating to rabbit skin.
Eye irritation:
A Draize test was performed with two New Zealand White rabbits, comparable to OECD guideline 405. Eyes were left unwashed after application of one sharp-edged spoon of the undiluted, solid test substance and were observed for 72 h. The mean score for conjunctivae redness was 0.16 in the treated eye, but was reversible within 72 h. In the control eyes, the mean conjunctivae redness score was also 0.16, reversible within 72 h. Scores for cornea, iris and chemosis were 0 at any reading time point in the treated eyes. It was concluded that the test substance is not irritating to the eyes.
Justification for classification or non-classification
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for irritation under Regulation (EC) No. 1272/2008, as amended for the 13th time in Regulation (EU) 2018/1480.
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