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Diss Factsheets
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EC number: 204-428-0 | CAS number: 120-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other: EU Risk Assessment
- Rationale for reliability incl. deficiencies:
- other: No reliability is given as this is a summary entry for the EU RAR.
- Principles of method if other than guideline:
- EU Risk Assessment
- GLP compliance:
- not specified
- Executive summary:
EU Risk Assessment, 2003:
1,2,4-TCB was toxic to soil microbiota as CO2 development was reduced at increasing concentrations. At 50µg/g sandy soil, the total CO2 evolution was depressed to approximately 50% of the normal and the turnover optimum measured as percent 1,2,4-TCB degradation was between 10 and 25µg/g during a 24 h study period (Marinucci and Bartha, 1979).
The toxicity of 1,2,4-TCB on terrestrial microorganisms was studied on a terrestrial bacterium by insertion of lux genes into the genome of Pseudominas fluorescens. The bioluminiscence was determined after 20 minutes of exposure to mono-, di-, tri-, tetra-, penta- and hexachlorobenzene. The toxicity increased with the chlorination. For 1,2,4-TCB, the EC50 was 18.3 mg/l (Boyd et al., 1998).
The test was performed with a soil bacteria, but in a short-term test in an aqueous solution.
Reference
EU Risk Assessment (2003):
1,2,4-TCB was toxic to soil microbiota as CO2 development was reduced at increasing concentrations. At 50µg/g sandy soil, the total CO2 evolution was depressed to approximately 50% of the normal and the turnover optimum measured as percent 1,2,4-TCB degradation was
between 10 and 25µg/g during a 24-hour study period (Marinucci and Bartha, 1979).
The toxicity of 1,2,4-TCB on terrestrial microorganisms was studied on a terrestrial bacterium by insertion of lux genes into the genome of Pseudominas fluorescens. The bioluminiscence was determined after 20 minutes of exposure to mono-, di-, tri-, tetra-, penta- and hexachlorobenzene. The toxicity increased with the chlorination. For 1,2,4-TCB, the EC50 was 18.3 mg/l (Boyd et al., 1998). The test was performed with a soil bacteria, but in a short-term test in an aqueous solution.
Description of key information
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
EU Risk Assessment, 2003:
1,2,4-TCB was toxic to soil microbiota as CO2 development was reduced at increasing concentrations. At 50µg/g sandy soil, the total CO2 evolution was depressed to approximately 50% of the normal and the turnover optimum measured as percent 1,2,4-TCB degradation was between 10 and 25µg/g during a 24 h study period (Marinucci and Bartha, 1979).
The toxicity of 1,2,4-TCB on terrestrial microorganisms was studied on a terrestrial bacterium by insertion of lux genes into the genome of Pseudominas fluorescens. The bioluminiscence was determined after 20 minutes of exposure to mono-, di-, tri-, tetra-, penta- and hexachlorobenzene. The toxicity increased with the chlorination. For 1,2,4-TCB, the EC50 was 18.3 mg/l (Boyd et al., 1998).
The test was performed with a soil bacteria, but in a short-term test in an aqueous solution.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.