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EC number: 203-128-7 | CAS number: 103-61-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Sensitization:
No sensitization reactions were observed in any of the volunteers. Hence, Cinnamyl butyrate can be considered to be not sensitizing to human skin.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal sensitization potential of cinnamyl butyrate in humans
- GLP compliance:
- not specified
- Type of study:
- other: Human Maximization study
- Justification for non-LLNA method:
- not specified
- Specific details on test material used for the study:
- - Name of the test material: Cinnamyl butyrate
- IUPAC name: (2E)-3-phenylprop-2-en-1-yl butanoate
- Molecular formula: C13H16O2
- Molecular weight: 204.267 g/mol
- Substance type: Organic
- Smiles: c1(\C=C\COC(CCC)=O)ccccc1
- Physical State: Colorless liquid - Species:
- other: humans
- Strain:
- not specified
- Sex:
- male
- Details on test animals and environmental conditions:
- no data available
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 4% petrolatum, 2760 µg/cm2
- Day(s)/duration:
- five alternate-day 48-h periods
- Adequacy of induction:
- other: Patch sites were pre-treated for 24 h under occlusion with 5% aqueous sodium lauryl sulfate (SLS) for the initial patch only.
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- % (2760 µg/cm2) cinnamyl butyrate in petrolatum
- Day(s)/duration:
- 48 h
- Adequacy of challenge:
- other: Challenge applications were preceded by 30-min applications of 5% aqueous SLS under occlusion on the left side of the back.
- No. of animals per dose:
- 29 healthy male volunteers
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 5
- Exposure period: 48-h periods
- Test groups: 29 healthy volunteers
- Control group: no data available
- Site: forearms of all volunteers
- Frequency of applications: five alternate-day 48-h periods
- Duration: 48-h periods
- Concentrations: 4% (2760 µg/cm2) cinnamyl butyrate in petrolatum
B. CHALLENGE EXPOSURE
- No. of exposures: single
- Day(s) of challenge: Following a 10–14 day rest period
- Exposure period: 48 hours
- Test groups:
- Control group: A fifth site was challenged with SLS on the left and petrolatum controls on the right.
- Site: right side of the back
- Concentrations: undiluted
- Evaluation (hr after challenge): 48 hours
OTHER:
Patch sites were pre-treated for 24 h under occlusion with 5% aqueous sodium lauryl sulfate (SLS) for the initial patch only. Challenge applications were preceded by 30-min applications of 5% aqueous SLS under occlusion on the left side of the back. - Challenge controls:
- no data available
- Positive control substance(s):
- not specified
- Positive control results:
- no data available
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 4% (2760 µg/cm2) cinnamyl butyrate in petrolatum .
- No. with + reactions:
- 0
- Total no. in group:
- 29
- Clinical observations:
- no sensitization reactions observed
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- No sensitization reactions were observed in any of the volunteers. Hence, Cinnamyl butyrate can be considered to be not sensitizing to human skin.
- Executive summary:
A maximization test was carried out to assess the dermal sensitization potential of Cinnamyl butyrate. Application of 4% (2760µg/cm2) cinnamyl butyrate in petrolatum was made under occlusion to the same site on the forearms of 29 healthy, male volunteers for five alternate-day 48-h periods. Patch sites were pre-treated for 24 h under occlusion with 5% aqueous sodium lauryl sulfate (SLS) for the initial patch only. Following a 10–14 day rest period, challenge patches were applied under occlusion to fresh sites for 48 h. Challenge applications were preceded by 30-min applications of 5% aqueous SLS under occlusion on the left side of the back, whereas the test material without SLS treatment was applied on the right side. A fifth site was challenged with SLS on the left and petrolatum controls on the right.
No sensitization reactions were observed in any of the volunteers. Hence, Cinnamyl butyrate can be considered to be not sensitizing to human skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin Sensitization:
Various studies were reviewed for dermal sensitization potential of Cinnamyl butyrate to ascertain its degree of sensitization. The studies include human and predicted data for the target chemical as well its structurally similar read across chemicals,Citronellyl isobutyrate [CAS: 97-89-2] and Cinnamyl propionate[CAS: 103-56-0].
A maximization test was carried out (Food and Chemical Toxicology, 45, (2007), S62–S65) to assess the dermal sensitization potential of Cinnamyl butyrate. Application of 4% (2760µg/cm2) cinnamyl butyrate in petrolatum was made under occlusion to the same site on the forearms of 29 healthy, male volunteers for five alternate-day 48-h periods. Patch sites were pre-treated for 24 h under occlusion with 5% aqueous sodium lauryl sulfate (SLS) for the initial patch only. Following a 10–14 day rest period, challenge patches were applied under occlusion to fresh sites for 48 h. Challenge applications were preceded by 30-min applications of 5% aqueous SLS under occlusion on the left side of the back, whereas the test material without SLS treatment was applied on the right side. A fifth site was challenged with SLS on the left and petrolatum controls on the right.
No sensitization reactions were observed in any of the volunteers. Hence, Cinnamyl butyrate can be considered to be not sensitizing to human skin.
The skin sensitization potential of Cinnamyl butyrate was estimated by SSS (2017) using OECD QSAR toolbox v3.3 with log kow as the primary descriptor. Cinnamyl butyrate was predicted to be non sensitizing to the skin of male Dunkin- Hartley guinea pigs.
Skin sensitization effects were also estimated by four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra used within Danish QSAR database for Cinnamyl butyrate. Based on estimation, no skin sensitization reactions were observed in guinea pigs and humans. Therefore, cinnamyl butyrate was considered to be non sensitizing.
The experimental and estimated results are in agreement with each other indicating a strong possibility of cinnamyl butyrate being not sensitizing to skin.
These results are supported by the experimental study summarized in Food and Cosmetics Toxicology, Volume 16, Supplement 1, 1978, Pages 693; for the structurally similar read across substance, CITRONELLYL ISOBUTYRATE [CAS: 97-89-2]. 25 volunteers were exposed to test chemical at concentration of 4% in petrolatum for 48 hours and then observations were made for any skin reactions.
None of the subject elicited any skin sensitizing reactions. Hence, Citronellyl isobutyrate (CAS No: 97-89-2) was considered to be not sensitizing to the skin of 25 volunteers.
The above results are further supported by the experimental study summarized in Food and Chemical Toxicology, 45, (2007), S1–S23; for the structurally similar read across substance, Cinnamyl propionate[CAS: 103-56-0]. Application of 4% (2760µg/cm2) cinnamyl propionate in petrolatum was made under occlusion to the same site on the forearms of 25 healthy, male volunteers for five alternate-day 48-h periods. Patch sites were pretreated for 24 h with 5% aqueous sodium lauryl sulfate (SLS) under occlusion before induction exposure. After 10 days rest period, challenge application given for 48hr having same concentration as induction exposure.
Challenge applications were preceded by 30-min applications of 5% aqueous SLS under occlusion on the left side of the back, whereas the test material without SLS treatment was applied on the right side. A fifth site was challenged with SLS on the left and petrolatum controls on the right.
No sensitization reactions were observed in any of the volunteers. Hence, Cinnamyl propionate can be considered to be not sensitizing to human skin.
Based on the available data for the target as well as read across substances and applying the weight of evidence approach,Cinnamyl butyrate was not sensitizing to skin.Comparing the above annotations with the criteria of CLP regulation, test chemical can be classified under the category “Not Classified”.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Available data for Cinnamyl butyrate suggests that it is not likely to cause any dermal sensitization to skin.
Cinnamyl butyrate can be considered to be not sensitizer to skin and can be classified under the category “Not Classified” as per CLP regulation.
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