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EC number: 201-321-0 | CAS number: 81-07-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide is not expected to show acute toxicity effect by the oral, inhalation and dermal route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 17 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Toxic effects not reported.
- Mortality:
- Lethal dose, 50 percent kill
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in mouse was found to be 17000 mg/kg of body weight. Acute toxicity of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide to mouse by the oral route indicates that the substance does not exhibits acute toxicity by the oral route within the mentioned dose level.
- Executive summary:
The acute oral median lethal dose (LD50) of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in mouse was found to be 17000 mg/kg of body weight. Acute toxicity of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide to mouse by the oral route indicates that the substance does not exhibits acute toxicity by the oral route within the mentioned dose level.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 17 000 mg/kg bw
- Quality of whole database:
- The data is K2 level as the data has been obtained from the experimental study from the reliable journal ‘Experientia’.Based upon this available data it is expected that the test chemical 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibit acute oral toxicity to mouse within the mentioned dose level.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Hazards Substances Act (Revised Federal Register Sept 17 1964)
- Principles of method if other than guideline:
- Standard acute method
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 694 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Lethal dose ; 50 percent kill
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal median lethal dose (LD50) of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in rabbit was found to be 4694 mg/kg of body weight. Acute toxicity of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide to rabbit by dermal route indicates that 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibits acute toxicity by the dermal route within the doses mentioned in the study.
- Executive summary:
The acute dermal median lethal dose (LD50) of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in rabbit was found to be 4694 mg/kg of body weight. Acute toxicity of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide to rabbit by dermal route indicates that 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibits acute toxicity by the dermal route within the doses mentioned in the study.
Reference
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O AND Group 16 - Sulfur S by Chemical elements
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= -0.845
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 4.6
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 694 mg/kg bw
- Quality of whole database:
- The data is K2 level as the data has been obtained from the QSAR model considered by OECD.Based upon this available data it is expected that the test chemical 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibit acute dermal toxicity to rabbit within the mentioned dose level.
Additional information
Acute toxicity: oral
No. of studies reviewed for acute oral toxicity from reliable sources having Klimisch rating 1 and 2.
The summary of the results are presented below
Sr.No |
Endpoint |
Effect values |
Species |
CAS No. |
Sources |
1 |
LD50 |
17000 mg/kg bw |
Mouse |
81-07-2 |
Publication data for Target Cas |
2 |
LD50 |
>2000 mg/kg |
Mouse |
81-07-2 |
Publication data for Target Cas |
3 |
LD50 |
17000 mg/kg bw |
Rat |
Read Across 128-44-9 |
Publication data for Read across Cas |
4 |
LD50 |
8440 - 9710 mg/kg bw |
Rat |
Read Across 128-44-9 |
Experimental data from BASF. |
5 |
LD50 |
14200± 1300 mg/kg bw |
Rat |
Read Across 128-44-9 |
Publication data for Read across Cas |
By applying weight of evidence approach to the target chemical 1,2-benzisothiazol-3(2H)-one 1,1-dioxide and the read across chemical 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt (which have more than 87.8 % structural similarity), the endpoint value was found to vary between>2000 mg/kgto 17000 mg/kg bw thus it is concluded that 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibits acute toxicity by the oral route within the mentioned dose level.
Acute toxicity inhalation
The acute inhalation median lethal concentration (LC50) of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in rat was found to be 815.265 mg/L air. Acute toxicity of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide to rat by inhalation route indicates that 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibits acute toxicity by the inhalative route within the doses mentioned in the study.
Acute toxicity dermal
The acute dermal median lethal dose (LD50) of1,2-benzisothiazol-3(2H)-one 1,1-dioxide in rabbit was found to be 4694 mg/kg of body weight. Acute toxicity of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide to rabbit by dermal route indicates that 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibits acute toxicity by the dermal route within the doses mentioned in the study.
Justification for selection of acute toxicity – oral endpoint
The acute oral median lethal dose (LD50) of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in mouse was found to be 17000 mg/kg of body weight. Acute toxicity of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide to mouse by the oral route indicates that the substance does not exhibits acute toxicity by the oral route within the mentioned dose level.
Justification for selection of acute toxicity – inhalation endpoint
The particle size distribution of the test substance was found to vary in the size of 500 – 600 µm, so the potential for the generation of inhalable forms is low. Moreover the normal conditions of use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be unlikely to occur, and therefore acute toxicity by inhalation route was considered to be waived.
Justification for selection of acute toxicity – dermal endpoint
The acute dermal median lethal dose (LD50) of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in rabbit was found to be 4694 mg/kg of body weight. Acute toxicity of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide to rabbit by dermal route indicates that 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibits acute toxicity by the dermal route within the doses mentioned in the study.
Justification for classification or non-classification
Based upon the study results and available information, the substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide is not expected to show acute toxicity effect by the oral, inhalation and dermal route and thus will not be considered for further classification.
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