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EC number: 201-280-9 | CAS number: 80-46-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Davoren and Fogarty (2005), provides a 48-hr LC50 of 2.7 mg/L for Daphnia magna. McLesse et al. (1981) provided a 96hr LC50 of 1.7 mg/L, based on mortality, with the marine invertebrate, the shrimp, Crangon septemspinosa.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.7 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 1.7 mg/L
Additional information
Reliable (Klimisch 1 or 2) short-term toxicity studies with invertebrates have been conducted for p-tert-amylphenol and are included in this dossier.
Davoren and Fogarty (2005) conducted a reliable (Klimisch 2) study according to British Standard Guideline (BS EN ISO 6341, 1996) with sodium p-tert-amylphenol with multiple species. Data obtained from tests using the salt is assumed to be representative of the parent substance due to its weak acid properties. Daphnia magna, <24 hrs old, were exposed to nominal concentrations (0.5 – 5.0 mg/L) of the test substance for 48-hrs. The 48-hr EC50, based on immobilization, for D. magna was 2.7 mg/L. Additionally, Thamnocephalus platyurus, fairy shrimp, larvae were exposed to the test substance following test guidelines presented in the Thamnotoxkit F (Alcontrol Laboratories, England). The 24-hr LC50 was 2.1 mg/L, based on mortality.
Wang et al. (2005) conducted a limit test (Klimisch 3) with p-tert-amylphenol using adult Daphnia magna. Although a preferred endpoint, such as LC50, was not presented, the study authors evaluated the stimulation of male offspring production and anti-juvenoid activity. The NOEC was determined to be >1.0 mg/L. Although this study result cannot be used in development of PNECs, it is presented in the dossier to provide weight of evidence to classification.
Gerrtisen et al. (1998) conducted a study following methods similar to OECD 202 with p-tert-amylphenol. Less than 24 hrs old Daphnia magna were exposed to the test substance for 96 hours. Although the preferred endpoint of 48hr LC50 was not obtained and organisms were fed daily during the test, the study presents a 96-hr NOEC of 1.8 mg/L based on mortality. This study result cannot be used in development of PNECs, but is presented in the dossier to provide weight of evidence to classification.
The short-term toxicity of sodium p-tert-amylphenol exposed to marine invertebrates was investigated by Daveoren and Fogarty (2005) (Klimisch 2). Data obtained from tests using the salt is assumed to be representative of the parent substance due to its weak acid properties. The invertebrate, brine shrimp (Artemia salina), was exposed to the test chemical for 24 hours following British Standard Guidelines. The 24 -hour LC50, based on mortality, was 6.5 mg/L.
The short-term toxicity of p-tert-amylphenol exposed to marine invertebrates was investigated by McLeese et al. (1981) (Klimisch 2). The marine invertebrate, shrimp (Crangon septemspinosa), was exposed to the test chemical for 96 hours. The 96 -hour LC50, based on mortality, was 1.7 mg/L.
Reliable (Klimisch 2) short-term toxicity studies with invertebrates have been conducted for p-tert-amylphenol and sodium p-tert-amylphenol and are included in this dossier. The key study, Davoren and Fogarty (2005), provides a 48-hr LC50 of 2.7 mg/L for Daphnia magna. Consequently this value will be taken as the short-term toxicity in aquatic invertebrate’s endpoint for p-tert-amylphenol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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