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Diss Factsheets
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EC number: 201-061-8 | CAS number: 77-83-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion negative (EU B46); eye irritation negative (OECD 405).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In Harlan study No. 41104025, to OECD 439 and to GLP, an in vitro test, using Human Reconstructed Epidermis (RHE) model, the test substance was found to be negative for skin irritation. According to Commission Regulation EC No. 761/2009, amending Commission Regulation EC No. 440/2008 (Test Methods Regulation), this method, referred to as EU method B.46, "may allow determining the skin irritancy of substances as a stand-alone replacement test within a testing strategy, in a weight of evidence approach". Further in vivo testing for this endpoint can be discounted on animal welfare grounds, thus avoiding potential pain and suffering of animals.
In Haarman & Reimer study No. 01732 to OECD 405, and to GLP, in vivo eye irritation study, the substance was found to be not irritating to eyes. An in vitro eye irritation test was not required because of the existence of this in vivo study.
Justification for classification or non-classification
Skin irritation/corrosion
According to Regulation (EC) No. 1272/2008, sections 3.2.2.6 and 3.2.2.7, for skin irritation/corrosion substances can be classified as skin corrosive category 1, skin irritant category 2 or not classified. The substance was found to be non-irritant, and should therefore not be classified for skin irritation or corrosion.
Eye irritation
Regulation (EC) No. 1272/2008, sections 3.3.2.6. and 3.3.2.7 cover "Irreversible effects on the eye/serious damage to eyes (Category 1)" and "Reversible effects on the eye (Category 2) respectively". Haarman & Reimer (2000) found that the substance was not irritating to eyes, interpreting the data in accordance with Directive 93/21/EEC rather than the later Regulation EC No. 1272/2008. Re-interpretation of these data in accordance with the criteria laid out in Regulation (EC) No. 1272/2008 clearly show that the original conclusion is also consistent with that regulation. The substance should therefore not be classified with regards to eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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