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Anness III inventarju

Anness III inventarju

L-ECHA kkompilat inventarju tas-sustanzi li aktarx jilħaq il-kriterji ta' Anness III għar-Regolament REACH. L-għan hu li jiġu mgħejjuna r-reġistranti fl-identifikazzjoni dwar jekk humiex meħtieġa rekwiżiti ta' informazzjoni minima mnaqqsa jew informazzjoni sħiħa ta' Anness VII.

L-inventarju sar minn bażijiet ta' data disponibbli pubblikament b'data sperimentali u permezz tar-riżultati tal-mudell (Q)SAR. L-indikazzjonijiet għal proprjetajiet tossikoloġiċi jew ekotossikoloġiċi perikolużi flimkien ma' informazzjoni dwar l-użu u informazzjoni disponibbli relevanti oħra għandhom jitqabblu mal-kriterji f'Anness III.

Il-fatt li sustanza mhix fil-lista ma jfissirx neċessarjament li ma ntlaħqux il-kriterji ta' Anness III. B'mod simili, jekk sustanza qiegħda fl-inventarju, reġistrant jista' xorta waħda jibbenefika mir-rekwiżiti ta' informazzjoni mnaqqsa jekk din tkun ġustifikata.

Innota li l-inventarju mhuwiex għodda għal klassifikazzjoni, juri biss indikazzjonijiet għal tħassib. Pereżempju, il-fatt li sustanza hija indikata bħala "Mutaġenu suspettat" ma jfissirx li l-ECHA tikkunsidraha bħala mutaġenu kklassifikat. Għandha tiġi kkunsidrata l-evidenza kollha qabel issir konklużjoni dwar il-bżonn għal klassifikazzjoni.

Benzo[def]chrysene

EC / List no.: 200-028-5 CAS no.: 50-32-8
Information source
# Harmonised classification for aquatic toxicity: The substance is listed in Annex VI of CLP as: Aquatic Acute 1; The substance is listed in Annex VI of CLP as: Aquatic Chronic 1 # Harmonised classification for carcinogenicity: The substance is listed in Annex VI of CLP as: Carc. 1B # Harmonised classification for mutagenicity: The substance is listed in Annex VI of CLP as: Muta. 1B # Harmonised classification for reprotoxicity: The substance is listed in Annex VI of CLP as: Repr. 1B # Harmonised classification for skin sensitisation: The substance is listed in Annex VI of CLP as: Skin Sens. 1 # Suspected bioaccumulative: Bioaccumulation Canada database in the Toolbox reports at least one value above the B threshold of 2,000 L/Kg (3.3 log units); EpiSuite data included in the Toolbox contain at least one experimental log Kow value equal to or higher than 4.5 # Suspected carcinogen: The Toolbox profiler 'Carcinogenicity (genotox and nongenotox) alerts by ISS' gives an alert for carcinogenicity; CAESAR Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (EXPERIMENTAL value); ISS Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (EXPERIMENTAL value); IARC monographs classified the substance as carcinogenic or probably/possibly carcinogenic; carcinogen according to ISSCAN; reasonably anticipated to be a human carcinogen according to NTP 13th RoC # Suspected hazardous to the aquatic environment: Fathead Minnow toxicity model (EPA) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 0.2662 mg/L (moderate reliability); Fish toxicity classification (SarPy/IRFMN) model in VEGA (Q)SAR platform predicts that the chemical is 'Toxic-2 (between 1 and 10 mg/l) (good reliability)'; Fish Acute Toxicity model (KNN/Read-Across) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 1.03 mg/L (moderate reliability) # Suspected mutagen: The Toolbox profiler 'DNA alerts for AMES, MN and CA by OASIS v.1.3' gives an alert for mutagenicity; The Toolbox profiler 'in vitro mutagenicity (Ames test) alerts by ISS' gives an alert for mutagenicity; CAESAR Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); ISS Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); KNN Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (good reliability); SARPY Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); The outcome in CTA assay is positive according to ISSCTA; In vivo micronucleus test outcome positive according to ISSMIC; mutagen according to ISSSTY # Suspected persistent in the environment: The Danish QSAR database contains information indicating that the substance is predicted as non readily biodegradable # Suspected skin sensitiser: CAESAR skin sensitisation model in VEGA (Q)SAR platform predicts that the chemical is Sensitizer (EXPERIMENTAL value) # Suspected toxic for reproduction: The Toolbox profiler 'DART scheme v.1.0' gives an alert for toxicity to reproduction;Developmental/Reproductive Toxicity library (PG) in VEGA (Q)SAR platform predicts that the chemical is Toxicant (EXPERIMENTAL value); DART database in the Toolbox reports that this substance as Known developmental potential

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