Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 433-400-2 | CAS number: 4245-76-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A guinea pig maximisation test was initiated to determine sensitising properties of CA 2342 A after challenge exposure by skin contact. The procedure of Magnusson and Kligman for adjuvant tests was followed. Epidermal challenge of 10 male and 10 female guinea pigs (test groups) resulted in no positive responses in all guinea pigs after 24 hours and 48 hours, corresponding to a sensitisation rate of 0%. No irritant skin reactions were recorded for control animals. Based on these results, classification of CA 2342 A (Intermediate of CGA 293343) as to its sensitising properties is not required. A LLNA assay was not performed (see comments in study report "LLNA waived").
Migrated from Short description of key information:
Based on the sensitization rate of 0%, which is below the threshold of significance (i.e. below 30%) set in Commission Directive 93/21/EEC (18th
adaptation to technical progress of Council Directive 67/548/EEC), classification of CA 2342 A as to its sensitising properties is not required.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
