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EC number: 406-750-9 | CAS number: 129757-67-1 TINUVIN 123
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral LD50 rat > 2000 mg/kg bw; transient signs of toxicity: Piloerection, hunched posture, exophthalmos, and dyspnea (OECD 401; 1989)
Dermal LD50 rat > 2000 mg/kg bw; transient signs of toxicity: Piloerection, abnormal body positions, and dyspnea (OECD 402; 1989)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature - Species:
- other: rat, Tif:RAI f (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CIBA-GEIGY Limited, Animal Production, Switzerland
- Age at study initiation: Young adult 6 to 8 weeks
- Weight at study initiation: 177 to 205 g
- Fasting period before study: fasted overnight
- Housing: group-housed = 5 animals per cage
- Diet (e.g. ad libitum): Rat chow (NAFAG 890 Tox, NAFAG,Gossau, Switzerland) was provided ad libitum.
- Water (e.g. ad libitum): water were provided ad libitum
- Acclimation period: at least for 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 + 2
- Humidity (%): 55 + 10 %.
- Air changes (per hr): approximately 15
- Photoperiod (hrs dark / hrs light): 12 hour/12 hour - Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5 % (w/v) carboxymethylcellulose in 0.1 % (w/v) aqueous polysorbate 80 (prepared by Pharmaceuticals Division, Ciba-Geigy Ltd,, Basel)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg body weight
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality was observed twice daily at a.m. and p.m. on working days and a.m. on weekend days. Signs and symptoms were noticed daily. Body weight was examined immediately before administration and on days 7 and 14.
- Necropsy of survivors performed: yes, at the end of the observation period. - Statistics:
- From the body weights, the group means and their standard deviations were calculated.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No signs of specific toxicity
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Piloerection, hunched posture, exophthalmos, and dyspnea were seen, being common symptoms in acute tests. The animals recovered within 5 to 6 days.
- Gross pathology:
- At autopsy, no deviations from normal morphology were found.
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- guideline study
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- other: rat, Tif:RAIf (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CIBA-GEIGY Limited, Animal Production, Switzerland
- Age at study initiation: Young adult initial age 7 to 8 weeks
- Weight at study initiation: 211 to 235 g
- Housing: individually housed
- Diet (e.g. ad libitum): Rat chow (NAFAG 890 Tox, NAFAG,Gossau, Switzerland) was provided ad libitum.
- Water (e.g. ad libitum): water was provided ad libitum
- Acclimation period: for at least 5 days before exposure
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 55 +/- 10
- Air changes (per hr): approximately 15
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- % coverage: at least 10% of the body surface
REMOVAL OF TEST SUBSTANCE
- Washing (if done): cleaned with lukewarm water
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 ml/kg body weight - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality was observed twice on working days and once on weekend days. Signs and symptoms were noticed daily. Body weight was observed immediately before application and on days 7 and 14.
- Necropsy of survivors performed: yes, at the end of the observation period. - Statistics:
- From the body weights, the group means and their standard deviations were calculated.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No signs of specific toxicity.
- Mortality:
- No mortality occurred in this study.
- Clinical signs:
- other: Piloerection, abnormal body positions, and dyspnea were seen, being common symptoms in acute dermal tests. The animals recovered within 5 days.
- Gross pathology:
- At autopsy, no deviations from normal morphology were found.
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- guideline study
Additional information
Oral
A GLP conform study was performed to assess the acute toxicity following oral administration of the test substance in albino rats (Tif: RAI f) according to OECD guideline 401 (1989). To a group of ten fasted animals (five males and five females) a single oral dose of the test material preparation (dose volume: 10 ml/kg bw) in 0.5% (w/v) carboxymethylcellulose in 0.1 % (w/v) aqueous polysorbate 80 at a dose level of 2000 mg/kg body weight was given. Piloerection, hunched posture, exophthalmos, and dyspnea were seen, being unspecific symptoms in acute tests. The animals recovered within 5 to 6 days. The expected body weight gain was observed in the course of the study. No mortality occurred in this study. At autopsy, no deviations from normal morphology were found. Under the conditions of this study the median lethal dose of the test substance after oral application was found to be greater than 2000 mg/kg body weight for the male and female animals.
Dermal
A GLP conform study was performed to assess the acute toxicity following dermal administration of the test substance in albino rats (Tif: RAI f) according to OECD guideline 402 (CIBA-Geigy, 1989). To a group of ten animals (five males and five females) a single dermal dose of the test material preparation (dose volume: 2 ml/kg bw) was given undiluted at a dose level of 2000 mg/kg body weight. Piloerection, abnormal body positions, and dyspnea were seen, being unspecific symptoms in acute dermal tests. The animals recovered within 5 days. The expected body weight gain was observed in the course of the study. No mortality occurred. At autopsy, no deviations from normal morphology were found. Under the conditions of this study the median lethal dose of the test substance after oral application was found to be greater than 2000 mg/kg body weight for the male and female animals.
Inhalation
not performed
Justification for classification or non-classification
Classification,
Labelling, and Packaging Regulation (EC) No 1272/2008
The
available experimental test data are reliable and suitable for
classification purposes under Regulation (EC) No 1272/2008. LD50 for
acute oral toxicity was greater than 2000 mg/kg bw. As a result the
substance is not considered to be classified for acute toxicity under
Regulation (EC) No 1272/2008.
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