Registration Dossier
Registration Dossier
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EC number: 233-046-7 | CAS number: 10025-87-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Year:
- 1 978
- Bibliographic source:
- TSCATS: OTS 0534840, Doc. ID. 88-920000388
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- phosphorus oxychloride
- IUPAC Name:
- phosphorus oxychloride
- Details on test material:
- phosphorus oxychloride; no data on purity of the compound
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: undiluted
- Doses:
- 25.1, 31.6, 39.8, and 50.1 mg/kg
- No. of animals per sex per dose:
- 5
- Details on study design:
- Groups of 5 Sprague-Dawley albino rats were given the undiluted test substance at dose levels of 25.1, 31.6, 39.8, and 50.1 mg/kg and were observed for 14 days.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 36 mg/kg bw
- 95% CL:
- > 31 - < 46
- Mortality:
- Five, 3, and 2 animals given 50.1, 39.8, and 31.6 mg/kg, respecively, died. Late deaths were reported; deaths occurred at 2 to 13 days after dosing.
- Clinical signs:
- other: Signs of intoxication included weight loss, increasing weakness, and collapse. Gross autopsy revealed hemorrhagic lungs, areas of liver discolouration, and acute gastro-intestinal inflammation. Viscera of the surviving animals appeared normal after 14 day
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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