Registration Dossier
Registration Dossier
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EC number: 927-431-5 | CAS number: 1178896-82-6
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- Oct - Nov 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD guideline under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- (9aR,11aS)-9a,11a-dimethyl-1-oxo-1H,2H,3H,3aH,3bH,4H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl acetate
- EC Number:
- 927-431-5
- Cas Number:
- 1178896-82-6
- Molecular formula:
- C26 H38 O4
- IUPAC Name:
- (9aR,11aS)-9a,11a-dimethyl-1-oxo-1H,2H,3H,3aH,3bH,4H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl acetate
- Details on test material:
- - Name of test material (as cited in study report): Dienolacetat-ketal (ZK 67985)
- Lot/batch No.: 51537013-021
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 200 mg/L
- Based on:
- ThOD/L
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 29 d
Any other information on results incl. tables
The test compound ZK 67985 was degraded to 0% on day 29 (28 days of incubation). The reference compound sodium acetate was degraded to 87% on day 6 and to 96% on day 29 (28 days of incubation).
In the toxicity control, the reference compound (sodium acetate) plus the test compound
ZK 67985, was degraded to 45% on day 29 (28 days of incubation), which reflected the degradation in the individual sets.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The test compound ZK 67985 is not readily biodegradable under the conditions of the test and it was not toxic to the microbes of activated sludge.
- Executive summary:
The purpose of this study was to detennine the ready biodegradability of Dienolacetat-ketal (ZK 67985), which is an
intermediate of the synthesis of different estrogens. The study was conducted in agreement with the OECD test guideline no. 301F.
The test substance was incubated in an aqueous solution including nutrients with microorganisms from a municipal sewage treatment plant for 28 days.The biological degradation of the test and reference substances was evalua.ted by measurement of
the O2 consumption during the test period.
The test compound Dienolacetat-ketal was degraded to 0% on day 29 (28 days of incubation) Accordingly, Dienolacetat-ketal is not readily biodegradable under the conditions of the test and it was not toxic to the microbes of activated sludge.
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