Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 84/449/EWG, B.12; OECD 474 (1981)
GLP compliance:
yes
Type of assay:
micronucleus assay

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
402-400-4
EC Name:
-
Cas Number:
54660-00-3
Molecular formula:
C18H12N2O2
IUPAC Name:
3,6-diphenyl-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione

Test animals

Species:
hamster, Chinese
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
0.5 % waterless sodium-carboxymethylcellulose
No. of animals per sex per dose:
Male: 5000 mg/kg; No of animals: 24; Sacrifice time: 16 hour
Male: 5000 mg/kg; No of animals: 24; Sacrifice time: 24 hour
Male: 5000 mg/kg; No of animals: 24; Sacrifice time: 48 hour
Female: 5000 mg/kg; No of animals: 24; Sacrifice time: 16 hour
Female: 5000 mg/kg; No of animals: 24; Sacrifice time: 24 hour
Female: 5000 mg/kg; No of animals: 24; Sacrifice time: 48 hour

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative