Registration Dossier
Registration Dossier
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EC number: 402-400-4 | CAS number: 54660-00-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, B.3; OECD 402 (1981)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 402-400-4
- EC Name:
- -
- Cas Number:
- 54660-00-3
- Molecular formula:
- C18H12N2O2
- IUPAC Name:
- 3,6-diphenyl-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar KFM-han. (SPF-quality)
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- polyethylene glycol
- Remarks:
- PEG 400
- Duration of exposure:
- 24 h
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- Male: 2000 mg/kg bw; No. of animals: 5; No. of death: 0
Female: 2000 mg/kg bw; No. of animals: 5; No. of death: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: No signs of toxicity.
- Gross pathology:
- Effects on organs:
No macroscopic changes. - Other findings:
- Signs of roxicity (local):
The pigment gave the treated skin a reddish colour.
No signs of toxicity.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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