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Diss Factsheets
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EC number: 449-410-5 | CAS number: 18084-64-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The mutagenic potential of the test substance was evaluated in two Salmonella/microsome tests with the S. typhimurium strains TA 98, TA 100, TA 1535, 1538 and TA 1537 in the presence and absence of S9 mix in a test protocol generally following OECD TG 471. Deviation from guideline was the absence of a strain which detects cross-linking mutagens (e.g. TA 102). Both tests, a plate incorporation and the preincubation test, with up to and including cytotoxic and precipitating concentrations indicate that the test substance is not a mutagen in the Ames Salmonella/microsome test.
To investigate the potential of the test item to induce chromosomal breakage (structural chromosomal aberrations) or misdistribution of chromosomes (aneuploidy) in vivo, a bone marrow micronucleus test was performed on mice. Ten male and ten female mice in the high dose group and 5 males/females in the mid and low dose group were treated intraperitoneally with single doses of 500, 1000, or 2000 mg/kg bw. Control animals (10 males/ 10 females) were given the vehicle (Myrj 52) in the same manner. The test item showed neither a biologically relevant nor statistically signficant increase in micronucleated polychromatic (PCE) and normochromatic erythrocytes (NCE) as compared to the negative control at either of the two sampling times (24 and 48 hours). The decrease of the PCE/NCE ratio indicated bone marrow depression induced by toxicity of the test substance. One male mouse died in the high-dose group. Thus, the test substance was negative in the mouse bone marrow micronucleus assay up to the recommended and toxic dose level of 2000 mg/kg bw.
Short description of key information:
Two gene mutation assays in bacteria (Ames plate incorporation and preincubation bacterial reverse mutation assays, GLP, comparable to OECD TG 471): negative in the Salmonella typhimurium strains TA 1535, TA 1537, TA 100, TA 1538 and TA 98 with and without S9 mix up to and including cytotoxic concentrations
Chromosome aberration in vivo (mouse micronucleus test, GLP, comparable to OECD TG 474): negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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