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EC number: 605-637-3 | CAS number: 172529-93-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21.08.2007 - 17.10.2007
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,3-dimethyl 2-[2-(2-amino-6-chloro-9H-purin-9-yl)ethyl]propanedioate
- Cas Number:
- 172529-93-0
- Molecular formula:
- C12 H14 Cl N5 O4
- IUPAC Name:
- 1,3-dimethyl 2-[2-(2-amino-6-chloro-9H-purin-9-yl)ethyl]propanedioate
- Reference substance name:
- 2-Amino-6-chloro-9-(methyl-2-carbomethoxybutanoate-4- yl)purine
- IUPAC Name:
- 2-Amino-6-chloro-9-(methyl-2-carbomethoxybutanoate-4- yl)purine
- Details on test material:
- Formula: C12H14ClN5O4
Appearence: White to pale yellow solid
Expiry date: 31 December 2007
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)IGS BR.
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: A suspension in an aqueous solution of 0.1% Na- carboxymethylcellulose was used.
- Doses:
- limit test 2000 mg/kg
- No. of animals per sex per dose:
- 2 groups with 3 animals; in total 6 females
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 0
- Clinical signs:
- other: Signs of toxicity related to dose levels: No toxic signs were found at animal observation during the entire observation period. A body weight gain in 5/6 animals in both weeks p.a. was noticed, but no body weight gain in 1/6 animals in the 2nd we
- Gross pathology:
- Effects on organs:
No findings were noted at post mortem examination.
Any other information on results incl. tables
Findings in life and post mortem indicate no toxic effects present.
Presence of signs in life: no signs
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
According to REGULATION (EC) No 1272/2008 (CLP) "Fam-stage-1" does not require classification for acute oral toxicity.
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