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EC number: 611-930-7
CAS number: 60045-26-3
The objective of the study was to assess the safety of benzyl benzoate lotion and permethrin as topical treatments for scabies during pregnancy. The population studied comprised refugee and migrant women attending antenatal clinics on the Thai-Burmwese border between August 1993 and April 2006. The study concluded that there was no evidence of adverse effects on pregnancy outcome due to topical application of 25% benzyl benzoate lotion or 4% permethrin.
Women treated with either BBL (25%) or permethrin (4%) were identified
from a manual search of antenatal records. Each case of scabies was
matched with four scabies-free controls for gravidity, age, smoking
status, malaria, period of treatment and gestational age at treatment.
Conditional Poisson regression was used to estimate risk ratios for
outcomes of pregnancy (proportion of abortions, congenital
abnormalities, neonatal deaths, stillbirths and premature babies), mean
birthweight and estimated median gestational age, for scabies and
scabies-free women, independently for BBL and permethrin.
There were no statistically significant differences in pregnancy
outcomes between women who were treated with either BBL (n = 444)
compared with their matched controls (n = 1,776) or permethrin (n = 196)
treated women and their matched controls (n = 784). Overall, only 10.9%
(n = 66) of treatments were in the first trimester. Retreatment rates
were higher with BBL 16.4%, than permethrin 9.7%, P = 0.038. Scabies was
more common during cooler periods.
There was no evidence of adverse effects on pregnancy outcome due to
topical 25% BBL or 4% permethrin
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