Registration Dossier
Registration Dossier
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EC number: 218-491-7 | CAS number: 2163-00-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- according to BASF-interal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,6-dichlorohexane
- EC Number:
- 218-491-7
- EC Name:
- 1,6-dichlorohexane
- Cas Number:
- 2163-00-0
- Molecular formula:
- C6H12Cl2
- IUPAC Name:
- 1,6-dichlorohexane
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- 2 mL
- Duration of treatment / exposure:
- 20 h
- Observation period:
- 8 d
- Number of animals:
- 2
- Details on study design:
- Application area: 2.5 x 2.5 cm2
SCORING SYSTEM: BASF internal scoring translated to Draize Scores.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- erythema score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: time point 48 h and 72 h not reported
- Irritation parameter:
- edema score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: time point 48 h and 72 h not reported
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- 1,6-Dichlorohexane was irritating to the skin of rabbits.
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