Registration Dossier
Registration Dossier
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EC number: 218-491-7 | CAS number: 2163-00-0
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with column 2 of REACH annex IX, a long-term toxicity to fish test (required in section 9.1.6) is not necessary as the chemical safety assessment according to Annex I does not indicate the need to investigate further the effects on aquatic organisms. One long-term aquatic study (algae) is available. This specie is more sensitive to the test substance in acute tests than fish. The RCRs were well below 1.
The substance is manufactured and handled in the closed system. Thus, exposure of the aquatic compartment is unlikely.
Furthermore, in the biodegradation test (see section 5.2.1), the substance 1,6-Dichlorohexane is classified as not readily biodegradable in the 10-d-window and after 61 days according to OECD guideline no. 310. However, the biodegradation of the test item came to 54 % after 61 days showing biodegradation with longer exposure times. Thus, long-term exposure of the environment is expected low due to the biodegradation of the substance.
Further long-term testing with fish would consequently not improve the risk assessment. Thus, in conclusion, also considering animal welfare reasons, further long-term testing with fish is not required.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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