4'-aminoazobenzene-4-sulphonic acid

Endpoint summary

Description of key information

Biodegradation in water

Estimation Programs Interface Suite (EPI suite, 2018) was run to predict the biodegradation potential of the test compound in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that the test chemical is expected to be not readily biodegradable.

 

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2018) prediction model was run to predict the half-life in water and sediment for the test compound. The Test chemical If released in to the environment, 16.2% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical in water is estimated to be 37.5 days (900 hrs.)The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of Test chemical in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into sediment is less than 1 %( i.e., reported as 0.129%) indicates that test chemical is not persistent in sediments.

 

Biodegradation in soil

The half-life period of Test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2018). If released into the environment, 83.7 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low. 

Additional information

Biodegradation in water

Various experimental studies have been investigated for the test chemical along with the predicted data for reviewing the biodegradation endpoint which have been summarized as below;

 

In a prediction using the Estimation Programs Interface Suite (2018), the biodegradation potential of the test compoundchemicalin the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that the test chemical is expected to be not readily biodegradable.

 

The above result was supported by Biodegradation study conducted for 28 days for evaluating the percentage biodegradability of test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be1.1 and <0% by BOD, O2 consumption, TOC removal, test mat. analysis and UV-Vis parameter in 28 days. Thus, based on percentage degradation, the test substance was considered to be not readily biodegradable in nature.

 

The above results were further supported by the Biodegradation study conducted for 14 days for evaluating the percentage biodegradability of test substance. The study was performed according to OECD Guide-line 301 C "Ready Biodegradability: Modified MITI Test (I)" under aerobic conditions. Aniline was used as a reference substance for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. Reference substance undergoes >40% and >60% degradation in 7 and 14 days, respectively. The percentage degradation of test substance was determined to be 0 and <0% degradation by BOD, O2 consumption, TOC removal, Test mat. analysis and UV-Vis parameter in 14 days. Thus, based on percentage degradation, the test chemical was considered to be not readily biodegradable in nature.

 

Based on the available data,it can be concluded that the testchemical can be expected to be not readily biodegradable in nature.

 

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2018) prediction model was run to predict the half-life in water and sediment for the test compound. The Test chemical If released in to the environment, 29% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical in water is estimated to be 15 days (360 hrs.)The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of Test chemical in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into sediment is less than 1 %( i.e., reported as 0.0692%) indicates that test chemical is not persistent in sediments.

 

Biodegradation in soil

The half-life period of Test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2018). If released into the environment, 83.7 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.