N,N,N',N'-tetramethyltrimethylenediamine

Endpoint summary

Description of key information

No data on toxicokinetics, metabolism and distribution are available for N, N, N', N'-tetramethyltrimethylenediamine. Based on its physico-chemical properties, N, N, N', N'-tetramethyltrimethylenediamine is expected to be well absorbed by the respiratory and gastro-intestinal tracts and through the skin.

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Absorption rate - oral (%):

100

Absorption rate - dermal (%):

100

Absorption rate - inhalation (%):

100

Additional information

There is no toxicokinetics, metabolism and distribution data available on N, N, N', N'-tetramethyltrimethylenediamine (TMPDA). Therefore, the assessment of the toxicokinetics of TMPDA is based on the available toxicological data and the physicochemical properties as suggested by the REACH Guidance Chapter R.7c:

Molecular weight: 130.23 g/mole

Water solubility: 598 g/L at 25°C

Partition coefficient log Kow = 0.29

ABSORPTION

Oral route

According to the REACH Guidance, the physicochemical characteristics of TMPDA (log Kow = 0.29) and the molecular mass (130.23 g/mol) are in a range suggestive of absorption as such from the gastro-intestinal tract subsequent to oral ingestion. This assumption of oral absorption is supported by the mortality and the clinical signs observed in the acute oral toxicity study in rats from the dose level of 312 mg/kg bw and upward (BASF, 1974). Therefore, the oral absorption of TMPDA is assumed to be 100% for risk assessment.

Inhalation route

According to the REACH Guidance, the physicochemical characteristics of TMPDA (log Kow = 0.29) and the molecular mass (130.23 g/mol) are in a range suggestive of absorption as such from the respiratory tract subsequent to an inhalation exposure. This assumption of inhalation absorption is supported by the mortality observed in the acute inhalation toxicity studies (Smyth et al., 1969; BASF, 1974). Therefore, the inhalation absorption of TMPDA is assumed to be 100% for risk assessment.

Dermal absorption

According to the REACH Guidance, the n-Octanol/water partition coefficient (log Kow), the water solubility and molecular weight of TMPDA are in ranges which favour dermal absorption. This assumption of dermal absorption is supported by the mortality observed in the acute dermal toxicity studies (Smyth et al., 1969; BASF, 1982). In such circumstances, a default value of 100% skin absorption is generally used.

DISTRIBUTION and METABOLISM

According to the REACH Guidance, as a small molecule a wide distribution of TMPDA is expected.

The metabolism of most simple aliphatic tertiary amines proceeds through biological oxidation of the amine to an amine oxide. 

ELIMINATION

As tertiary amine oxides are stable and water soluble, they are filtered by the kidney and undergo primarily urinary excretion.

According to the REACH Guidance, the n-Octanol/water partition coefficient is not suggestive of accumulation of unchanged TMPDA in fatty tissues subsequent to absorption.