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EC number: 204-634-0 | CAS number: 123-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 986
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- Principles of method if other than guideline:
- Draize test.
Female New Zealand White rabbits were tested for eye irritation. 0.1 mL of undiluted 2,4-pentanedione was instilled into the lower conjunctival sac of one eye per animal or was placed directly on the eye. The eyelids were held together for a second. The effects were scored according to Draize at one hour, approximately 6 hours, one day, 2 days, 3 days and 7 days after dosing. Fluorescein (2 %) staining was used to determine corneal injury before dosing and at readings after one day. - GLP compliance:
- not specified
Test material
- Details on test material:
- Purity: >99%
Physical state: yellow, transparent non-viscous liquid
Lot No.: 496-500
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- single application without washing
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: no washing performed.
SCORING SYSTEM: Draize scheme
TOOL USED TO ASSESS SCORE:
Fluorescein (2%) staining was used to determine corneal injury before dosing and at readings after one day.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: No effects on the cornea were observed throughout the study period.
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Remarks on result:
- other: No effects were observed throughout the study period.
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Slight effects were only observed after 1 and 4 hours.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Slight effects were only observed after 1 and 4 hours.
- Irritant / corrosive response data:
- After 1 h:
Slight redness of the conjunctivae was observable in 5/6 animals (average score 0.8). Slight chemosis in 2/6 and moderate chemosis in 1/6 animals (average score 0.7); slight discharge in 2/6 and moderate discharge in 3/6 animals (average score 1.3); slight inflammation of the iris in 2/6 animals (average score 0.3).
After 4 h:
Slight inflammation of the iris in 1/6 animals (score 0.2); slight redness of the conjunctivae in 4/6 animals (average score 0.7); slight chemosis in 2/6, moderate chemosis in 1/6 animals (average score 0.7); slight conjunctival discharge in 3/6 and moderate conjunctival discharge in 2/6 animals (average score 1.2).
24 hours post-instillation all eyes healed. Opacities of the cornea were not observable at any time.
Any other information on results incl. tables
Table 1: Individual eye scores of the six rabbits at 1, 4, 24, 48, and 72 h after beginning of the treatment.
Animal |
|
|
conjunctivae |
|
|
cornea |
iris |
redness |
Chemosis |
1 |
|
|
|
|
1 h |
0 |
0 |
1 |
1 |
4 h |
0 |
0 |
1 |
1 |
24 h |
0 |
0 |
0 |
0 |
48 h |
0 |
0 |
0 |
0 |
72 h |
0 |
0 |
0 |
0 |
Mean (24-72 h) |
0 |
0 |
0 |
0 |
|
|
|
|
|
2 |
|
|
|
|
1 h |
0 |
0 |
0 |
0 |
4 h |
0 |
0 |
0 |
0 |
24 h |
0 |
0 |
0 |
0 |
48 h |
0 |
0 |
0 |
0 |
72 h |
0 |
0 |
0 |
0 |
Mean (24-72 h) |
0 |
0 |
0 |
0 |
|
|
|
|
|
3 |
|
|
|
|
1 h |
0 |
0 |
1 |
0 |
4 h |
0 |
0 |
1 |
0 |
24 h |
0 |
0 |
0 |
0 |
48 h |
0 |
0 |
0 |
0 |
72 h |
0 |
0 |
0 |
0 |
Mean (24-72 h) |
0 |
0 |
0 |
0 |
|
|
|
|
|
4 |
|
|
|
|
1 h |
0 |
0 |
1 |
0 |
4 h |
0 |
0 |
0 |
0 |
24 h |
0 |
0 |
0 |
0 |
48 h |
0 |
0 |
0 |
0 |
72 h |
0 |
0 |
0 |
0 |
Mean (24-72 h) |
0 |
0 |
0 |
0 |
|
|
|
|
|
5 |
|
|
|
|
1 h |
0 |
1 |
1 |
2 |
4 h |
0 |
1 |
1 |
2 |
24 h |
0 |
0 |
0 |
0 |
48 h |
0 |
0 |
0 |
0 |
72 h |
0 |
0 |
0 |
0 |
Mean (24-72 h) |
0 |
0 |
0 |
0 |
|
|
|
|
|
6 |
|
|
|
|
1 h |
0 |
1 |
1 |
1 |
4 h |
0 |
0 |
1 |
1 |
24 h |
0 |
0 |
0 |
0 |
48 h |
0 |
0 |
0 |
0 |
72 h |
0 |
0 |
0 |
0 |
Mean (24-72 h) |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not eye irritating under the evaluated conditions of this study.
- Executive summary:
6 New Zealand White rabbits received treatment of 0.1 mL of the undiluted test substance.
No washing was performed. Readings were performed 1, 4, 24, 48 and 72h after administration. The observation period was 7 days.
The test substance did not show eye irritating properties.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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