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Diss Factsheets
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EC number: 608-770-5 | CAS number: 326894-55-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19.-25.06.2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- European Commission Regulation (EC) No. 440/2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- column elution method
- Key result
- Water solubility:
- < 0.044 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- > 5.6 - < 5.7
- Conclusions:
- The water solubility at a temperature of 20 °C was determined to be below the quantification limit: < 0.044 mg/L.
- Executive summary:
The water solubility was determined according to OECD 105 using the column elution method with HPLC analysis . Therefore, two identical columns were prepared; one of them was exposed to a flow rate of about 12.5 mL/h (column 1), the other one to 25.0 mL/h (column 2). The concentration of test item was determined by means of HPLC. The volumes of all fractions were measured. For the analysed fractions the pH values and the temperatures were measured, too. For column 1 the fractions 21 to 25 were evaluated. The water solubility was found to be smaller than 0.044 mg/L. For column 2 the fractions 49 to 53 were evaluated. The water solubility was found to be smaller than 0.044 mg/L. The water solubility at a temperature of 20 °C was determined to be below the quantification limit: < 0.044 mg/L.
Reference
Preliminary Visual Estimation of the Water Solubility
The solubility of the test item in water was found to be below 8.6 mg/L (without correction for the purity). According to the guideline the column elution method is the appropriate method for solubilities below 10 mg/L therefore this method was used for the main test.
Appearance of the test mixtures
Amount of the test item in mg | Total volume in mL | Appearance of mixture |
17.1 | 100 | undissolved |
12.0 | 500 | undissolved |
4.3 | 500 | undissolved |
Concentration and pH
Column 1
Fraction | V | pH | water solubility |
21 | 18.0 | 5.6 | < 44 |
22 | 18.0 | 5.7 | < 44 |
23 | 18.0 | 5.7 | < 44 |
24 | 18.0 | 5.7 | < 44 |
25 | 18.0 | 5.7 | < 44 |
The water solubility was found to be below the quantification limit of 44 μg/L.
Column 2
Fraction | V | pH | water solubility |
49 | 18.5 | 5.7 | < 44 |
50 | 18.5 | 5.7 | < 44 |
51 | 18.5 | 5.7 | < 44 |
52 | 18.5 | 5.7 | < 44 |
53 | 18.5 | 5.7 | < 44 |
The water solubility was found to be below the quantification limit of 44 μg/L.
Coating check: The coating check was successful. Enough residual test item remained an the columns.
Description of key information
The water solubility at a temperature of 20 °C was determined to be below the quantification limit: < 0.044 mg/L.
Key value for chemical safety assessment
Additional information
The water solubility was determined according to OECD 105 using the column elution method with HPLC analysis. Therefore, two identical columns were prepared; one of them was exposed to a flow rate of about 12.5 mL/h (column 1), the other one to 25.0 mL/h (column 2). The concentration of test item was determined by means of HPLC. The volumes of all fractions were measured. For the analysed fractions the pH values and the temperatures were measured, too. For column 1 the fractions 21 to 25 were evaluated. The water solubility was found to be smaller than 0.044 mg/L. For column 2 the fractions 49 to 53 were evaluated. The water solubility was found to be smaller than 0.044 mg/L. The water solubility at a temperature of 20 °C was determined to be below the quantification limit: < 0.044 mg/L.
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