Tetradecafluorohexane

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

November 2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 211 (Daphnia magna Reproduction Test)

Deviations:

not applicable

Remarks:

QSAR model adapted specifically to test guideline: OECD 211.

Principles of method if other than guideline:

The chronic toxicity of the daphnids was determined using a validated QSAR model for the Mechanism of Action (MechoA) in question (MechoA 1.1, i.e. non-polar narcosis) (3). The QSAR is based on validated data for a training set of 30 chemicals derived from 21-day test on daphnids, for which the concentrations of the test item had been determined by chemical analyses over the test period.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Tetradecafluorohexane

EC Number:

206-585-0

EC Name:

Tetradecafluorohexane

Cas Number:

355-42-0

Molecular formula:

C6F14

IUPAC Name:

tetradecafluorohexane

Test material form:

liquid

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

Results from the following species were used in the regression:
Daphnia magna

Study design

Test type:

flow-through

Water media type:

not specified

Total exposure duration:

21 d

Test conditions

pH:

6-9

Results and discussion

Effect concentrations

Key result

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

0.072 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

not specified

Remarks on result:

other: the prediction relies on a water solubility not in accordance with experimental results.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The NOEC 21d predicted with this QSAR calculation, on the basis of a water solubility predicted to be 7.02 mg/L, is 0.072 mg/L.

However, in water solubility assay performed otherwise, poor water solubility combined with high volatility made impossible to solubilize tetradecafluorohexane at higher concentration than 0.02 mg/L after more than 24 hours. Moreover, the solubility assay was performed in closed vessel to minimize volatization, with continuous stirring, and the concentrations measured were probably far higher than what could be expected in the environment or in a long term toxicity assay on daphnia.

Therefore, it can reasonably be concluded that the 21d NOEC predicted is above the limit of solubility of tetradecafluorohexane.