Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-217-4 | CAS number: 516-03-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 15 October to 21 November 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- not specified
- Type of method:
- flask method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 18000205
- Expiration date of the lot/batch: 23 August 2023
- Purity test date:23 January 2018 - Key result
- Water solubility:
- 54.7 mg/L
- Temp.:
- 20 °C
- pH:
- 5
- Remarks on result:
- other: mean of three determinations
- Details on results:
- Preliminary test
A preliminary test was carried out as a range finding test prior to the main test. The concentration range obtained gives an indication on the necessary analytical method sensitivity.
Increasing volumes of water were added at room temperature to 27.7 mg of the test sample in a 100 mL glass-stoppered measuring cylinder. After each addition of an amount of water, the mixture was shaken for 10 minutes and was visually checked for any undissolved parts of the sample.
The approximate solubility deduced from the necessary volume of water in which complete dissolution of the sample occurred is given in the table below. - Conclusions:
- The water solubility of the test item has been determined by the shake flask method in pure water following the OECD Guideline 105.
The test item solubility in water at 20 ± 0.5 °C based on the mean of the three determinations with the shake flask method was determinated to be : 54.7 mg/L.
Reference
Preliminary test
| Volume of water added | Solubilisation? | Approximate solubility |
| 1 mL | No | - |
| 10 mL | No | - |
| 100 mL | No | - |
| Insoluble in 100 mL | < 0.2 g/L |
The test item (27.7 mg) was not solubilized by 100 mL of water after 24 h, corresponding to a water solubility inferior to 0.277 g/L.
Description of key information
The water solubility of the test item has been determined by the shake flask method in pure water following the OECD Guideline 105.
The test item solubility in water at 20 ± 0.5 °C based on the mean of the three determinations with the shake flask method was determinated to be : 54.7 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 54.7 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
