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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
April 16, 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The model is been assessed according to the OECD principles for the validation of QSAR, to generate a transparent, understandable, reproducible and verifiable result.

Data source

Reference
Reference Type:
review article or handbook
Title:
QSAR Application Toolbox Workflow
Author:
Laboratory of Mathematical Chemistry, Bourgas University “Prof. Assen Zlatarov”, Bulgaria
Year:
2017
Bibliographic source:
https://www.qsartoolbox.org/documents/21638082/21638271/1_qsar_toolbox_4_general_presentation_en.pdf

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Version / remarks:
ECHA Guidance on information requirements and chemical safety assessment - Chapter R.06: QSARs and grouping of chemicals
Principles of method if other than guideline:
Prediction was calculated using QSAR Toolbox v.4.2 Database version: 4.2

Test material

Constituent 1
Chemical structure
Reference substance name:
Trimethyl benzene-1,2,4-tricarboxylate
EC Number:
219-547-3
EC Name:
Trimethyl benzene-1,2,4-tricarboxylate
Cas Number:
2459-10-1
Molecular formula:
C12H12O6
IUPAC Name:
1,2,4-trimethyl benzene-1,2,4-tricarboxylate

Test animals

Species:
rabbit

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
2 460 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The acute dermal median lethal dose (LD50) in the rabbit was determined to be 2460 mg/kg bw
Executive summary:

The acute dermal median lethal dose (LD50) in the rabbit was determined to be 2460 mg/kg bw