(6S)-6-{propyl[2-(2-thienyl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride (1:1)

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

20 Nov 2017 - 20 Dec 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

2016

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

1995

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

(6S)-6-{propyl[2-(thiophen-2-yl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride

EC Number:

603-080-0

Cas Number:

125572-93-2

Molecular formula:

C19H25NOS*HCl

IUPAC Name:

(6S)-6-{propyl[2-(thiophen-2-yl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride

Test material form:

solid: particulate/powder

Details on test material:

- Appearance: White powder
- Storage condition of test material: At room temperature

Results and discussion

Melting / freezing point

Key result

Melting / freezing pt.:

184.4 °C

Any other information on results incl. tables

TGA EXPERIMENT (PRELIMINARY TEST)

Starting at 275°C, the weight of the sample decreased significantly. At 291°C, the sample weight had decreased by 25%.

After the experiment, a dark brown molten residue remained in the sample container.

The change of the colour indicated reaction and/or decomposition of the test item.

DSC EXPERIMENT 1

A strong endothermic effect was observed between 150°C and 200°C followed by a weak endothermic effect, i.e. gradual decrease of heat flow starting at 225°C. The extrapolated onset temperature of the endothermic peak was 184.619°C. The strong endothermic effect was most likely caused by melting of the test item. The weak endothermic effect was ascribed to reaction and/or decomposition of the test item.

After the experiment, an orange molten residue remained in the sample container. Based on this visual observation, it was concluded that the test item had molten and the change of the colour demonstrated reaction and/or decomposition of the test item.

DSC EXPERIMENT 2

In order to investigate the melting peak, in Experiment 2 heating was stopped directly after the melting peak. The extrapolated onset temperature was 184.126°C. After the experiment, a colourless molten residue remained in the sample container. It demonstrated that melting was the reason for the endothermic effect.

DATA HANDLING

The melting temperature was determined as the mean extrapolated onset temperature of Experiment 1 and Experiment 2.

Applicant's summary and conclusion

Conclusions:

The melting temperature of the substance was determined to be 184.4°C.

Executive summary:

Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.

The melting temperature of the substance was determined in duplicate obtaining a mean value of 184.4°C.

Reaction and/or decomposition of the substance started at 225°C.