Registration Dossier
Registration Dossier
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EC number: 946-365-8 | CAS number: -
Dermal absorption
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- Mathematical Model
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Source of data is from peer reviewed literature. Acceptable well-documented study report which meets basic scientific principles: non-GLP.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- dermal absorption, other
- Remarks:
- Mathematical Model
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Source of data is from peer reviewed literature. Acceptable well-documented study report which meets basic scientific principles: non-GLP.
- Reason / purpose for cross-reference:
- read-across source
- Signs and symptoms of toxicity:
- not examined
- Dermal irritation:
- not examined
- Conclusions:
- The diffusion coefficients (Dsc, cm2/min x 10^-8) of aromatic hydrocarbons were determined to be: Naphthalene 4.2+/-1.4; 1-Methyl naphthalene 4.6 +/-2.7; 2-Methyl naphthalene 4.5+/-2.6.
- Executive summary:
This data is being read across from the source study that tested Naphthalene, 1-methylnaphthalene, and 2-methylnaphthalene based on analogue read across.
A mathematical model was developed to describe the diffusion coefficients (Dsc) of aromatic hydrocarbons. The diffusion coefficients (Dsc, cm2/min x 10-8) of aromatic hydrocarbons were determined to be: Naphthalene 4.2+/-1.4; 1-Methyl naphthalene 4.6 +/-2.7; 2-Methyl naphthalene 4.5+/-2.6.
Data source
Reference
- Reference Type:
- publication
- Title:
- Mathematical description of the uptake of hydrocarbons in jet fuel into the stratum corneum of human volunteers.
- Author:
- Kim, David; Matthew W. Farthing; Cass T. Miller; Nylander-French, Leena A.
- Year:
- 2 008
- Bibliographic source:
- Toxicology Letters 178 (2008) 146-151
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A mathematical description/model was developed to describe the uptake of aromatic hydrocarbons into the stratum corneum of human skin in vivo. The dermal absorption data was gathered in a previous paper (Kim 2006).
Kim, D., Andersen, ME., Nylander-French, L.A., 2006a. Dermal absorption and penetration of jet fuel components in humans. Toxicol. Lett. 165, 11-21. - GLP compliance:
- no
Test material
- Reference substance name:
- Naphthalene
- EC Number:
- 202-049-5
- EC Name:
- Naphthalene
- Cas Number:
- 91-20-3
- Molecular formula:
- C10H8
- IUPAC Name:
- naphthalene
- Reference substance name:
- 1-methylnaphthalene
- EC Number:
- 201-966-8
- EC Name:
- 1-methylnaphthalene
- Cas Number:
- 90-12-0
- Molecular formula:
- C11H10
- IUPAC Name:
- 1-methylnaphthalene
- Reference substance name:
- 2-methylnaphthalene
- EC Number:
- 202-078-3
- EC Name:
- 2-methylnaphthalene
- Cas Number:
- 91-57-6
- Molecular formula:
- C11H10
- IUPAC Name:
- 2-methylnaphthalene
Constituent 1
Constituent 2
Constituent 3
Constituent 4
- Radiolabelling:
- no
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Control animals:
- no
Results and discussion
- Signs and symptoms of toxicity:
- not examined
- Dermal irritation:
- not examined
Applicant's summary and conclusion
- Conclusions:
- The diffusion coefficients (Dsc, cm2/min x 10^-8) of aromatic hydrocarbons were determined to be: Naphthalene 4.2+/-1.4; 1-Methyl naphthalene 4.6 +/-2.7; 2-Methyl naphthalene 4.5+/-2.6.
- Executive summary:
A mathematical model was developed to describe the diffusion coefficients (Dsc) of aromatic hydrocarbons. The diffusion coefficients (Dsc, cm2/min x 10-8) of aromatic hydrocarbons were determined to be: Naphthalene 4.2+/-1.4; 1-Methyl naphthalene 4.6 +/-2.7; 2-Methyl naphthalene 4.5+/-2.6.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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