Registration Dossier
Registration Dossier
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EC number: 208-408-2 | CAS number: 527-09-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- eye irritation in vivo (from QSAR prediction)
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Title:
- QSAR Toolbox 3.4.0.17 Prediction of MMAS in eye rabbit for copper di-d-gluconate
- Year:
- 2 018
- Bibliographic source:
- Modelo QSAR 180413 MMAS Gluconato
- Report date:
- 2018
Materials and methods
Test guideline
- Guideline:
- other: REACH guideline on QSAR
Test material
- Reference substance name:
- Copper di-D-gluconate
- EC Number:
- 208-408-2
- EC Name:
- Copper di-D-gluconate
- Cas Number:
- 527-09-3
- Molecular formula:
- C12H22CuO14
- IUPAC Name:
- copper(2+) bis(2,3,4,5,6-pentahydroxyhexanoate)
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- SMILES: OCC{P-}(O)C{P-}(O)C{P+}(O)C{P-}(O)C(=O)O{-}.[Cu]{+}
Results and discussion
In vivo
Results
- Irritation parameter:
- other: MMAS (Modified Maximum Avarage Score)
- Time point:
- other: not specified
- Score:
- 49.5
Applicant's summary and conclusion
- Interpretation of results:
- Category 2B (mildly irritating to eyes) based on GHS criteria
- Conclusions:
- The value obtained for MMAS of the prediction was 49.5, which indicates that the compound is midly toxic considering that the maximum value of damage in cornea conjunctive and iris is 110
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