Propane-1-thiol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1987-09-09

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

No information on GLP compliance

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)

Deviations:

yes

Remarks:

only one concentration was tested

GLP compliance:

not specified

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

Propane-1-thiol

EC Number:

203-455-5

EC Name:

Propane-1-thiol

Cas Number:

107-03-9

Molecular formula:

C3H8S

IUPAC Name:

propane-1-thiol

Details on test material:

- Name of test material (as cited in study report): propane-1-thiol

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River UK Ltd., Margate, Kent
- Age at study initiation: 6 to 8 weeks
- Housing: polypropylene cages that had detachable wire mesh tops and floors and were suspended on a movable rack
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

No data reported

Duration of exposure:

>= 4

Concentrations:

5.663 mg/L

No. of animals per sex per dose:

5 per sex per dose

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 5.663 mg/L air

Mortality:

There were no deaths following exposure to propane-1-thiol vapour at a concentration of 5.663 mg/L

Clinical signs:

other: other:

Body weight:

Food and water consumption was reduced among exposed males and females for 1 day. Weight gain by rats exposed to propane-1-thiol was reduced for 1 day (males) or up to 4 days (females) post exposure. No further data were presented.

Other findings:

Lung weight to bodyweight ratios were within normal limits for all rats with the possible exception of one that was exposed to propane-1-thiol vapour. No treatment-related findings were observed at gross necropsy (no further details presented in report).

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

This study reported no toxic effects in rabbits exposed via inhalation to propane-1-thiol.

Executive summary:

In an acute inhalation toxicity study, groups of young adult albino Sprague-Dawley rats (5/sex) were exposed by inhalation route to propane-1-thiol for 4 hours to whole body at a concentration of 5.663 mg/L. Animals then were observed for 14 days.

 

There were no deaths following exposure to propane-1-thiol vapour at a concentration of 5.663 mg/l. During exposure there were signs of irritant effects including partial closing of the eyes, reduced respiration rate, abnormal respiration movements and adoption of a hunched body posture. Rats showed increased respiratory rate immediately following exposure, which subsequently returned to normal. Weight gain by rats exposed to propane-1-thiol was reduced for 1 day for males or up to 4 days for females post exposure. The inhalation LC₅₀ was determined to be greater than 5.663 mg/l in males and females.

 

This study received a Klimisch score of 2 and is classified as reliable with restrictions because, although only summary results were presented, there was good data on test conditions and substance but no mention of GLP compliance.