Registration Dossier

Administrative data

Description of key information

Based on read across from PETMP, PETMA is assumed to be harmful if swallowed (LD50 = 1500 mg/kg bw) and non-toxic if inhaled (no mortality at highest attainable concentration).

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
see category report attached as "full study report"
Reason / purpose:
read-across source
Principles of method if other than guideline:
read across from PETMP using OECD QSAR Toolbox 4.2 using Structural Similarity as descriptor
Species:
rat
Route of administration:
oral: gavage
Key result
Dose descriptor:
LD50
Effect level:
1 500 mg/kg bw
Based on:
act. ingr.
Remarks:
read across from PETMP
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Based on read across from PETMP, PETMA is classified as Acute Tox 4 - H302
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 500 mg/kg bw
Quality of whole database:
read across from valid study

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
see category report attached as "full study report"
Reason / purpose:
read-across source
Principles of method if other than guideline:
read across from PETMP using OECD QSAR Toolbox 4.2 using Structural Similarity as descriptor
Species:
rat
Route of administration:
inhalation: aerosol
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 3 363 mg/m³ air (analytical)
Based on:
other: read across
Exp. duration:
4 h
Remarks on result:
not determinable due to absence of adverse toxic effects
Interpretation of results:
GHS criteria not met
Conclusions:
Based on read across from PETMP, the 4-h LC50 of PETMA is considered >3.36 mg/L which was the highest attainable concentration of PETMP. Since both substances haver similar visosities, they are assumed to have a similar behaviour when atomised.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LC50
Value:
3 360 mg/m³
Quality of whole database:
read across from valid study, no mortality at highest attainable concentration

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available
Quality of whole database:
not required since data on two other routes of exposure are available

Additional information

Justification for classification or non-classification

Based on read across from PETMP, PETMA is assumed to be harmful if swallowed (LD50 = 1500 mg/kg bw, Acute Tox 4, H302) and non-toxic if inhaled (no mortality at highest attainable concentration).