Registration Dossier
Registration Dossier
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EC number: 309-269-1 | CAS number: 100208-66-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For justification please refer to attached Read Across Statement in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: corresponding to > 0.04 mg/L mean measured
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 0.04 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mortality (fish)
- Remarks:
- or sublethal effects
- Remarks on result:
- other: the test item had no toxic effect on fish at aquatic saturation (i.e. limit test concentration)
Reference
Description of key information
In the 96-hour test according to OECD Guideline 203 on Danio rerio the read across substance Yellow 22 (CAS 90268 -98 -7) had no toxic effect on fish at aquatic saturation (i.e. limit test concentration). Accordingly, the 96 -h NOEC was determined to be 0.040 mg/L and the LOEC > 0.040 mg/L (based on total product), equivalent to 100 mg/L and > 100 mg/L nominal loading rate respectively.
Key value for chemical safety assessment
Additional information
The acute toxicity of the read across substance Yellow 22 (CAS 90268 -98 -7) to Danio rerio was determined in a 96 -hour semi-static test according to the Commission Regulation (EC) No 440/2008, Annex Part C, C.1 and OECD Guideline for Testing of Chemicals, Section 2, No. 203. The 96-h NOEC was determined to be 0.040 mg/L (equivalent to 100 mg/L nominal loading rate) and the LOEC > 0.040 mg/L (equivalent to > 100 mg/L nominal loading rate).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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