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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
06-04-2018 – 07-04-2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to guideline
Guideline:
other: granulometric analysis with rotap sieve shaker.
Principles of method if other than guideline:
The particle size distribution of test item Cetalkonium chloride (CAS No. 122-18-9 ) was determined by granulometric analysis with rotap sieve shaker.
GLP compliance:
no
Type of method:
sieving
Type of particle tested:
primary particle
Type of distribution:
counted distribution
Specific details on test material used for the study:
- Name of test material: Cetalkonium chloride
- IUPAC name: CETYL DIMETHYL BENZYL AMMONIUM CHLORIDE
- Molecular formula: C25H46ClN
- Molecular weight: 396.098 g/mole
- Smiles : c1(C[N+](CCCCCCCCCCCCCCCC)(C)C)ccccc1.[ClH-]
- Inchl: 1S/C25H46N.ClH/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20-23-26(2,3)24-25-21-18-17-19-22-25;/h17-19,21-22H,4-16,20,23-24H2,1-3H3;1H/q+1;/p-1
- Substance type: Organic
- Physical state: Solid (white)
- Purity: 99.7%
Key result
Percentile:
D50
Remarks on result:
other: Mass median diameter
No.:
#1
Size:
150 µm
Distribution:
26.398 %
Remarks on result:
other: No other detail available
No.:
#2
Size:
106 µm
Distribution:
42.533 %
Remarks on result:
other: No other detail available
No.:
#3
Size:
75 µm
Distribution:
26.368 %
Remarks on result:
other: No other detail available
No.:
#4
Size:
53 µm
Distribution:
3.921 %
Remarks on result:
other: No other detail available
No.:
#5
Size:
25 µm
Distribution:
0.78 %
Remarks on result:
other: No other detail available

OBSERVATION TABLE:

Amount of sample weighed (g) =10 gm

Method run time (minutes) =10 min

Weight of empty container (g) =0.301 gm

Sieve sizes(in microns)

Weight of container + test substance (g)

Sample quantity retained after sieving (g)

Percentage (%) of sample*

150 microns

47.202

2.572

26.3984

106 microns

48.602

4.144

42.5331

75 microns

49.184

2.569

26.3676

53 microns

54.335

0.382

3.9207

25 microns

48.803

0.076

0.7800

10 microns

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-

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Conclusions:
The particle size distribution of test item Cetalkonium chloride (CAS No. 122-18-9 ) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in the range of 10 micron to 150 micron.
Executive summary:

The particle size distribution of test item Cetalkonium chloride (CAS No. 122-18-9 ) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in the range of 10 micron to 150 micron.

Description of key information

The particle size distribution of test item Cetalkonium chloride (CAS No. 122-18-9 ) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in the range of 10 micron to 150 micron.

Additional information

The particle size distribution of test item Cetalkonium chloride (CAS No. 122-18-9 ) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in the range of 10 micron to 150 micron.