1,5-dinitronaphthalene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1996

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Acute oral toxicity in rats is available for the analogue molecule. In rats, an LD50 of 86 and 150 mg/kg/bw after intraperitoneal (i.p.) application was reported for 1-nitronaphthalene. These data were peer-reviewed and considered acceptable, original publications of Lewis (1996) and Dinsdale et al. (1987).
Read-across is justifiable for this endpoint because the Cramer rules in the OECD Toolbox classified both molecules under Class III- highly toxic, based on their expected level of oral toxicity (Lapenna and Worth, 2011). Considering the structural similarities of both molecules and the probability to act via a common mode of action, it is acceptable to classify the substance of interest as an Acute Toxicant, Category 3.
See attached justification for full reasoning.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Principles of method if other than guideline:

Guideline not specified, summary data from read-across report. These data were peer-reviewed and considered acceptable.

GLP compliance:

not specified

Remarks:

Read-across endpoint is taken from a collection of data - the GLP compliance is not specified. Studies were conducted in 1987 and 1996.

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-nitronaphthalene

EC Number:

201-684-5

EC Name:

1-nitronaphthalene

Cas Number:

86-57-7

Molecular formula:

C10H7NO2

IUPAC Name:

1-nitronaphthalene

Test material form:

solid: crystalline

Specific details on test material used for the study:

Read-across molecule, test material specifics are not available.

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

other: intraperitoneal

Vehicle:

not specified

Control animals:

not specified

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 86 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Lewis (1996)

Effect levels 2

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 150 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Dinsdale et al. (1987)

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

Acute oral toxicity in rats is available for the analogue molecule. In rats, an LD50 of 86 and 150 mg/kg/bw after intraperitoneal (i.p.) application was reported for 1-nitronaphthalene. These data were peer-reviewed and considered acceptable, original publications of Lewis (1996) and Dinsdale et al. (1987).

Read-across is justifiable for this endpoint because the Cramer rules in the OECD Toolbox classified both molecules under Class III- highly toxic, based on their expected level of oral toxicity (Lapenna and Worth, 2011). Considering the structural similarities of both molecules and the probability to act via a common mode of action, it is acceptable to classify the substance of interest as an Acute Toxicant, Category 3.

Executive summary:

Acute oral toxicity in rats is available for the analogue molecule. In rats, an LD50 of 86 and 150 mg/kg/bw after intraperitoneal (i.p.) application was reported for 1-nitronaphthalene. These data were peer-reviewed and considered acceptable, original publications of Lewis (1996) and Dinsdale et al. (1987).

Read-across is justifiable for this endpoint because the Cramer rules in the OECD Toolbox classified both molecules under Class III- highly toxic, based on their expected level of oral toxicity (Lapenna and Worth, 2011). Considering the structural similarities of both molecules and the probability to act via a common mode of action, it is acceptable to classify the substance of interest as an Acute Toxicant, Category 3.