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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1996
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Acute oral toxicity in rats is available for the analogue molecule. In rats, an LD50 of 86 and 150 mg/kg/bw after intraperitoneal (i.p.) application was reported for 1-nitronaphthalene. These data were peer-reviewed and considered acceptable, original publications of Lewis (1996) and Dinsdale et al. (1987).
Read-across is justifiable for this endpoint because the Cramer rules in the OECD Toolbox classified both molecules under Class III- highly toxic, based on their expected level of oral toxicity (Lapenna and Worth, 2011). Considering the structural similarities of both molecules and the probability to act via a common mode of action, it is acceptable to classify the substance of interest as an Acute Toxicant, Category 3.
See attached justification for full reasoning.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2017
Report Date:
2017

Materials and methods

Principles of method if other than guideline:
Guideline not specified, summary data from read-across report. These data were peer-reviewed and considered acceptable.
GLP compliance:
not specified
Remarks:
Read-across endpoint is taken from a collection of data - the GLP compliance is not specified. Studies were conducted in 1987 and 1996.
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Specific details on test material used for the study:
Read-across molecule, test material specifics are not available.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: intraperitoneal
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 86 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Lewis (1996)
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 150 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Dinsdale et al. (1987)

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
Acute oral toxicity in rats is available for the analogue molecule. In rats, an LD50 of 86 and 150 mg/kg/bw after intraperitoneal (i.p.) application was reported for 1-nitronaphthalene. These data were peer-reviewed and considered acceptable, original publications of Lewis (1996) and Dinsdale et al. (1987).

Read-across is justifiable for this endpoint because the Cramer rules in the OECD Toolbox classified both molecules under Class III- highly toxic, based on their expected level of oral toxicity (Lapenna and Worth, 2011). Considering the structural similarities of both molecules and the probability to act via a common mode of action, it is acceptable to classify the substance of interest as an Acute Toxicant, Category 3.
Executive summary:

Acute oral toxicity in rats is available for the analogue molecule. In rats, an LD50 of 86 and 150 mg/kg/bw after intraperitoneal (i.p.) application was reported for 1-nitronaphthalene. These data were peer-reviewed and considered acceptable, original publications of Lewis (1996) and Dinsdale et al. (1987).

Read-across is justifiable for this endpoint because the Cramer rules in the OECD Toolbox classified both molecules under Class III- highly toxic, based on their expected level of oral toxicity (Lapenna and Worth, 2011). Considering the structural similarities of both molecules and the probability to act via a common mode of action, it is acceptable to classify the substance of interest as an Acute Toxicant, Category 3.