Registration Dossier
Registration Dossier
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EC number: 207-321-7 | CAS number: 462-06-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature available. Peer-reviewed database.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Reference Type:
- secondary source
- Title:
- Toxicological Evaluations Vol. 13
- Author:
- BG Chemie
- Year:
- 1 998
- Bibliographic source:
- Springer-Verlag Berlin Heidelberg, ISBN 3-540-62658-1
Materials and methods
- Principles of method if other than guideline:
- 0.1 ml TS was instilled into the conjunctival sac of the rabbit eye either neat or as a 10, 5 or 1% solution in sesame oil. The eyes were examined 1, 3, 7, 24, 48 and 72 hours and 6 days after instillation.
- GLP compliance:
- no
Test material
- Reference substance name:
- Fluorobenzene
- EC Number:
- 207-321-7
- EC Name:
- Fluorobenzene
- Cas Number:
- 462-06-6
- Molecular formula:
- C6H5F
- IUPAC Name:
- fluorobenzene
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- other: sesame oil
- Amount / concentration applied:
- - Amount applied: 0.1 ml
- Concentration: undiluted, 10, 5 or 1% - Observation period (in vivo):
- 6 days
- Number of animals or in vitro replicates:
- 5
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- > 0
- Reversibility:
- not specified
- Remarks on result:
- other: after application of 0.1 ml undiluted TS
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- > 0
- Reversibility:
- not specified
- Remarks on result:
- other: after application of 0.1 ml undiluted TS
- Irritant / corrosive response data:
- The neat substance caused redness and severe cloudy swelling of the conjunctiva in all test animals. In addition 4 out of 5 rabbits showed slight clouding of the cornea (no data on reversibility). The dilutions had no irritant effects. Fluorobenzene was classified as severely irritating to the eye.
Any other information on results incl. tables
The neat substance caused redness and severe cloudy swelling of the conjunctiva in all test animals. In addition 4 out of 5 rabbits showed slight clouding of the cornea (no data on reversibility). The dilutions had no irritant effects. Fluorobenzene was classified as severely irritating to the eye.
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information
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